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Standardizing Pharmacology: Assays and Hormones
Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including ...
International Review of Neurobiology
International Review of Neurobiology
Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis
Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms m...
Thirty Years CINP
The development of modern psychopharmacology was triggered by two major discoveries: the psychomimetic effects of lysergic acid diethylamide (LSD-25) in 1943 and the therapeutic effects of chlorpromazine in 1952. In his opening address to the 1st CINP Congress in Rome, Rothlin pointed out that these discoveries gave "a great impetus for any kind of scientific approach to brain research" and had "revolutionary consequences in the treatment of psychotic patients". The incentive they provided "was not limited to theoretical and practical medical sciences but caused an even greater stimulus to the imagination of chemists, leading to the production of new compounds with a speed that neither pharm...
Abstracts
Abstracts of the Sixth International Congress of Pharmacology deals with papers submitted during the pharmacology congress held at Helsinki in 1975. This collection of papers deals with research and development in pharmacology and biotherapeutic drugs. The wide array of subjects deals with the therapeutic implications of controlled drug delivery and the methods of drug application, including pharmacological investigations on cell in a culture. The book also contains papers about the interactions of neurotransmitters and the hypothalamic releasing hormones and toxins as tools in receptor studies. Some papers also deal with behavioral pharmacology that covers drug dependence, narcotic analgesi...
Galanin
Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and tr...
Art, Aesthetics, and the Brain
Humans have engaged in artistic and aesthetic activities since the appearance of our species. Our ancestors have decorated their bodies, tools, and utensils for over 100,000 years. The expression of meaning using color, line, sound, rhythm, or movement, among other means, constitutes a fundamental aspect of our species' biological and cultural heritage. Art and aesthetics, therefore, contribute to our species identity and distinguish it from its living and extinct relatives. Science is faced with the challenge of explaining the natural foundations of such a unique trait, and the way cultural processes nurture it into magnificent expressions, historically and ethnically unique. How does the h...
Brain Architecture : Understanding the Basic Plan
Depending on your point of view the brain is an organ, a machine, a biological computer, or simply the most important component of the nervous system. How does it work as a whole? What are its major parts and how are they interconnected to generate thinking, feelings, and behavior? This book surveys 2,500 years of scientific thinking about these profoundly important questions from the perspective of fundamental architectural principles, and then proposes a new model for the basic plan of neural systems organization based on an explosion of structural data emerging from the neuroanatomy revolution of the 1970's. The importance of a balance between theoretical and experimental morphology is st...
Nobel Prizes: Genes, Viruses And Cellular Signaling
The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products.The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of s...
Pituitary, Adrenal and the Brain
Pituitary, Adrenal and the Brain
