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Role of Exosomes in Biological Communication Systems
This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
Nutritional Status Assessment and its Links with Chronic Disease Prognosis and Surgical Outcomes
Nutritional disorders are related to poor health outcomes including longer hospital stays, postoperative complications, cancer treatment toxicity, shorter survival, and reduced quality of life. The use of nutritional assessment tools for both diagnostic and outcome measure purposes has been widely explored. However, understanding of their responsiveness to nutritional interventions is still in its incipient stages. There has been increasing awareness of the importance of nutritional screening and assessment, especially the integration of skeletal muscle mass evaluation into clinical practice. In this context, a standardized definition of low muscle mass, myosteatosis, and muscle strength is ...
Crosstalk between Cell Death, Oxidative Stress, and Immune Regulation
Cell death, a biological event important for maintaining the growth, development, and life processes of organisms, mainly includes programmed death (apoptosis, pyroptosis, autophagy, mitochondrial apoptosis, ferroptosis, cuproptosis, and disulfidptosis, etc.) and non-programmed death (cell necrosis). Many diseases, including cancers, exhibit dysregulated immune activities as key features due to the increase in oxidative stress, which eventually leads to cell death. Understanding the intricate relationships between cell death, oxidative stress, and immune regulation could be critical in elucidating the key molecular mechanisms of these diseases, possibly uncovering novel therapeutics/diagnostics for disease management. For example, ferroptosis, a form of iron-dependent cell death that is triggered by the toxic accumulation of oxidative stress, can induce immunosuppression in tumor neutrophils, whereas inhibition of ferroptosis can slow tumor progression. For another example, pyroptosis, a form of lytic cell death which can be triggered by oxidative stress, when occurs in tumor cells, can induce a strong inflammatory response and significant tumor regression.
Paragangliomas: New Insights for the Healthcare Professional: 2011 Edition
Paragangliomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Paragangliomas in a compact format. The editors have built Paragangliomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Paragangliomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Paragangliomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Anterior Pituitary Hormones—Advances in Research and Application: 2012 Edition
Anterior Pituitary Hormones—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Anterior Pituitary Hormones. The editors have built Anterior Pituitary Hormones—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Anterior Pituitary Hormones in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Anterior Pituitary Hormones—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition
Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Diabetes, Endocrinology, and Hepatology. The editors have built Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diabetes, Endocrinology, and Hepatology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
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The Leading World’s Most Innovative Universities
This open access book is unique in its contents. No other title in the book market has tackled this important subject. It introduces innovation as a way of practice for world-class universities. It, then, discusses the criteria for being innovative in the academic world. The book selects some of the top innovative world-class universities to study the factors that qualified them to be innovative, so that any other university can follow their steps to become innovative. The final chapter of the book presents some recommendations in this regard.
The Abomination Assignment
What do a Palestinian gunman in Hamburg, an al-Qaida operative in Amsterdam, a Saudi bomber in Montreal and an American self-proclaimed "Prophet of the People" have in common? Dr. Thomas Bowin, noted neuroscientist and occasional government-sanctioned assassin is on a mission to hunt them down. If you want a tightly plotted procedural thriller well spiced with sex, violence, international intrigue and food, this is just the beginning of Tom Bowin's adventures.
