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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the thirteenth volume of a continuing series.
This Research Topic is the second volume of the Community Series, Reducing the Burden of Age-related Disease in relation to Osteoporosis, Sarcopenia and Osteosarcopenia. Please find the first Edition here. Osteoporosis is a common disease worldwide, resulting in nearly 9 million bone fractures globally per year. The number of people living with osteoporosis is set to dramatically increase in the coming decades, because of aging populations and lifestyle changes. Developing countries suffer more from osteoporosis due to limited availability of resources. Osteoporotic fractures are one of the most prevalent causes of disability and 1/3 women and 1/5 men >50 years will experience an osteoporoti...
Over the last few years, new high-throughput biotechnologies are revolutionizing our ways to utilize human biospecimens for understanding atherosclerotic disease. These recent advances allow deep profiling of individual cells at the genomics, epigenomics, transcriptomics and proteomics levels, or even simultaneous detection of various combinations of ‘Omics’ in the same cell. Additionally, novel methods to integrate data at different levels from tissue sections and dissociated tissues are the emerging trends in large and institutional biobank studies. Growing literature has shown the value of such sequencing and bioinformatic strategies in shedding light on (1) how risk genes, as identified by the Genome-Wide Association Study, contribute to atherogenesis (genotype to phenotype), and (2) how features of atherosclerotic lesions affect patient response in clinical trials (phenotype to the clinical outcome). The hybrid of cutting-edge biotechnologies and bioinformatic approaches helps us maximize biobank resources to accelerate bench-to-bedside research.
A city of stories – short, fragmented, amorphous, and at times contradictory – Tehran is an impossible tale to tell. For the capital city of one of the most powerful nations in the Middle East, its literary output is rarely acknowledged in the West. This unique celebration of its writing brings together ten stories exploring the tensions and pressures that make the city what it is: tensions between the public and the private, pressures from without – judgemental neighbours, the expectations of religion and society – and from within – family feuds, thwarted ambitions, destructive relationships. The psychological impact of these pressures manifests in different ways: a man wakes up t...
Tehran, the capital of Iran since the late eighteenth century, is now one of the largest cities in the Middle East. Exploring Tehran's development from the nineteenth to the mid-twentieth century, Ashkan Rezvani Naraghi paints a vibrant picture of a city undergoing rapid and dynamic social transformation. Rezvani Naraghi demonstrates that this shift was the product of a developing discourse around spatial knowledge, in which the West became the model for the social practices of the state and sections of Iranian society. As traditional social spaces, such as coffee houses, bathhouses, and mosques, were replaced by European-style cafes, theatres, and sports clubs, Tehran and its people were irreversibly altered. Using an array of archival sources, Rezvani Naraghi stresses the agency of everyday inhabitants in shaping urban change. This enlightening history not only allows us to better understand the contours of contemporary Tehran, but to develop a new way of imagining, talking about, and building 'the city'.
This book brings together a leading team of international experts in arts and global development to showcase effective practice and to explore how this vibrant interdisciplinary field has developed and what the latest research can teach us. Although arts play a central role in human development, and in the health and wellbeing of individuals and communities, few have attempted to comprehensively explore arts practice as global development. This Handbook first provides a theoretical framework for exploring arts and global development, before surveying a comprehensive range of art forms and development practices to explore the potential of the arts to strategically and beneficially contribute ...
1. A Brief History of Censorship in Iran from the Early Days of the Press until the 1979 Revolution -- 2. Laws, Theories and Policies of Censorship in the Islamic Republic of Iran -- 3. The Censor Machine: Strcuture and Mechanism, Operators, Changes and Variations -- 4. Censors at Work -- 5. Reward and Punishment: Different Tools for the Same End -- 6. How Do Writers and Poets React to Censorship? -- 7. How Is Censorship Affecting Iranian Literature? -- 8. Conclusion -- Notes and References -- Bibliography -- Index.