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Mitochondrial Dysfunction
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alteration...
Here Come the Cavalry!
Step into the thrilling and topsy-turvy history of professional soccer in Calgary with this captivating chronicle written by a former player, dedicated fan, and passionate journalist. From the Boomers and Kickers of the 1980s to the present-day Cavalry FC, this book unveils the fascinating history of Calgary's professional soccer teams. To set the stage, it delves into the short-lived tenures of Cavalry’s predecessors, explaining why they failed to endure. These brief ventures are contrasted with the decisions Cavalry FC has made to not only stay afloat as a professional sports franchise, but also to thrive and grow in the post-pandemic era. Bringing the narrative to life are in-depth inte...
Comprehensive Toxicology
Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.
Advances in Radiation Biology V14
Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emphasizes radiation sensitivity and radiobiology of tumors of the cervix of the female genital tract. Ch...
Integration of Mitochondrial Function
In aerobic tissues such as heart, brain, kidney, liver and brown fat, mitochon dria account for more than 20% of cell protein and play an essential role in res piration, ATP formation, ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis, thermogenesis and a variety of other metabolic activities. The mecha nisms by which these activities are integrated and regulated within the overall context of cellular physiology is of much current research interest. In order to bring together scientists examining the various diverse aspects of this overall pro blem, an International Conference on INTEGRATION OF MITOCHONDRIAL FUNC TION was held June 4-7, 1987 at the Hanes Art Center on the campus of the Uni versity of North Carolina at Chapel Hill. The chapters of this volume derive from presentations made at this conference. The focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi cant new experimental and theoretical advances concerning integration of mito chondrial function at the organelle, cell, tissue and whole organism levels of organization.
Pathophysiology of Cerebral Energy Metabolism
Introductory Remarks.- Pathophysiology of Cerebral Ischemia.- The Interpretation of Ultrastructural Abnormalities in Cerebral Ischemia.- Short-Term Unilateral Ischemia in Gerbils: A Reevaluation.- Some New Aspects of the Pathochemistry of the Post-Ischemic Period.- Blood Flow, Oxygen, and Electrical Dynamics in Cerebral Ischemia.- Cytochemistry of Hippocampus Following Cerebral Ischemia.- Cerebral Water and Electrolyte Content Following Ischemia and Blood-Brain Barrier Disturbances.- Behavior of the Blood-Brain Barrier (BBB) in Cerebral Ischemia.- Reemphasis of the Role of 5-Hydroxytryptamine.
Hydrolysis in Drug and Prodrug Metabolism
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Cell Reproduction
Cell Reproduction: In Honor of Daniel Mazia represents the proceeding of a symposium entitled "Cell Reproduction held in Keystone, Colorado, on March 1978. The symposium is organized to honor Daniel Mazia. Most of the areas of research that are discussed at the conference have their origins in Dan Mazia's laboratory. This volume is divided into nine parts, consisting of papers presented in the symposium. It first focuses on the macromolecular control in cell proliferation and growth, cell cycle regulation, control of genetic expression, and microtubule assembly in vitro and in vivo. In then explains the control of fertilization phenomena, chromosome movement, the mitotic apparatus, and control of cell division and cell cleavage. Lastly, this volume discusses the structural and molecular basis of cell movement and describes the differentiated cell. This book represents a tribute to Daniel Mazia's extraordinary contributions as teacher, scientist, and friend.
Drug-Induced Hepatotoxicity
The advances in science and medicine we are now experiencing are unprec edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effo...
