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This book addresses the basic and advanced knowledge on psychiatric disorders for non-clinicians. The volume compiles in-depth information on the psychopharmacogenetic, representing an important area of research that is based on various specialties including clinical psychiatry, pharmacology, neurobiology and genetics. The book also addresses questions related to the field of psychiatric disorders that are not usually addressed in one work. The questions considered include: What is schizophrenia? What are the risk factors? What are the core symptoms? How is it treated? What are the efficacy and side effects of the available treatments?
Hormonal Proteins and Peptides: ß-Endorphin, Volume X focuses on the chemistry, biology, and clinical investigations of opioid peptides. This book discusses the chemical approach in isolating a chemical entity from its natural source and investigates its biological activity after it has been determined to be a pure substance. Organized into nine chapters, this volume starts with an overview of the structure–activity relationship of ß-endorphin (ß-EP) by synthetic approach. This text then explores the proteinases involved in the generation of opioid peptides, including ß-EP from ß-lipotropin (ß-LPH). Other chapters review the biosynthesis of ß-EP and consider in detail the opiate receptor. This book discusses as well the anatomy of ß-EP-containing structures in pituitary and brain. The final chapter presents a discussion on the historical aspects of opiate–peptide discoveries, particularly in the field of narcotic antagonists. This book is a valuable resource for chemists, biologists, endocrinologists, physicians, and neurobiologists.
This volume is based on the program of the Second International Conference on Drugs of Abuse, Immunity and AIDS, held in Clearwater Beach, FL in June 1992. The Conference was supported in part by the University of South Florida College of MediCine with financial assistance from the National Institute on Drug Abuse. The focus of this conference was the effects of drugs of abuse on immunity. It is now widely recognized that psychoactive drugs of abuse, including marijuana, cocaine, and opiates, as well as alcohol, have marked effects in an individual, including effects on their nervous system and behavior. In the past two decades, the scope of studies concerning the effects of some drugs of ab...
The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.