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Chorea
Chorea: Causes and Management provides a comprehensive and timely update for the wide variety of neurological conditions, both inherited and acquired, which result in this common hyperkinetic movement disorder. This book describes in detail the latest clinical and etiological information regarding chorea. Management strategies, pathophysiology, and associated medical and psychiatric problems associated with chorea are also addressed. The nineteen chapters are contributed by internationally-recognized authors working at the forefront of research in the specific disorders linked to chorea. Chorea: Causes and Management is aimed at an audience of neurologists, psychiatrists, neuropsychologists, specialists in medical genetics, clinical and basic researchers in neurosciences, and generalist clinical physicians with an interest in movement disorders.
The Interface of Neurology & Internal Medicine
This book is the first comprehensive reference on the interface between neurology and internal medicine. In 171 chapters organized by organ system, the book examines the neurologic manifestations of dozens of medical conditions, the neurologic effects of drugs, organ transplantation, and other treatments, and the medical comorbidities or complications—iatrogenic or otherwise—that neurologists must diagnose and treat in patients with neurologic disease. Most chapters are co-authored by a neurologist and a non-neurologic specialist. Each chapter presents information in an accessible format and includes a case vignette and the authors' recommendations for the case. A companion Website provides a multiple-choice question for each chapter and the fully searchable text, with case vignettes and recommendations linked.
Parkinson's Disease: Current and Future Therapeutics and Clinical Trials
This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.
Molecular Mechanisms Involved in the Pathogenesis of Huntington's Disease
Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with a distinct phenotype, including chorea, incoordination, cognitive decline, and behavioural difficulties. The underlying genetic defect responsible for the disease is the expansion of a CAG repeat in the gene coding for the HD protein, huntingtin (htt). This CAG repeat is an unstable triplet repeat DNA sequence, and its length is inversely correlated with the age at onset of the disease. Expanded CAG repeats have been found in 8 other inherited neurodegenerative diseases. Despite its widespread distribution, mutant htt causes selective neurodegeneration, which occurs preferentially and most prominently in the striatum and deeper layers of the cortex. This book focuses on HD, outlining the effects of mutant htt in the nucleus and cytoplasm as well as the role of cell-cell interactions in the HD pathology.
A Patient's Perspective on Spastic Tetraparesis Diagnosis
There are books that discuss all types of cerebral palsy and provide guidelines for families of those who have it, but they do not describe specifically the spastic tetraparesis diagnosis. They address the plegia type of diagnosis and not the paresis one, yet these are two different conditions. They are mostly written from a doctor’s or physiotherapist’s point of view, and not by the patients themselves. This book is different, as it is written by someone with personal experience of receiving this diagnosis. It gives an overview of how the diagnosis of spastic tetraparesis affects the body at each level (face, hands, abdomen, lower limbs), as well as the challenges the diagnosed person faces in daily life, and ways to overcome these challenges (tools to make dressing easier, different walking aids along with their drawbacks and benefits, ways to be independent in carrying out activities, among others). It also explores the relationship between disability and sexuality.
Parkinson's Disease
Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials – and controversies and future challenges – are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an international team of specialists who bring their expertise to improving the management of this disease.
Neurología
Esta nueva edición del libro de texto Neurología especialmente pensado para alumnos de la carrera de Medicina que cursan la materia presenta una serie de novedades que representan los avances en el conocimiento que sucedieron en los últimos años. Los temas y capítulos correspondientes son los mismos que los de la edición anterior pero el contenido y diagramación han variado de acuerdo a las novedades que se desarrollaron en los últimos años. Se ha agregado un capítulo de rehabilitación, un área de la neurología de marcado crecimiento. Se han incluido nuevas ilustraciones y esquemas para que su lectura sea fácil y atractiva pero conservando la extensión de la edición anterior que es apta para el tiempo que los alumnos puedan dedicar a la materia.
Convivir con el Síndrome de las piernas inquietas
Nuevo título de la serie que ayuda a mejorar la calidad de vida de los pacientes. El síndrome de piernas inquietas es un cuadro frecuente, aunque poco conocido tanto por médicos, como por pacientes. Los síntomas son muy característicos e incluyen molestias vespertinas, en ocasiones dolorosas que afectan los miembros inferiores. Es característica la necesidad de movilizar las piernas, salir de la cama y caminar. De esta forma se alivian transitoriamente los síntomas. Hay formas secundarias de diversos procesos y otras en las que no hay causa evidente. Todas ellas tienen buenas oportunidades terapéuticas que necesariamente comienzan por el reconocimiento del problema. Esta obra ayuda a quienes padecen este síndrome a entenderlo y convivir con él con mejor calidad de vida.
