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This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.
This book collects a selection of the best articles presented at the CUPUM (Computers in Urban Planning and Urban Management) conference, held in the second week of July 2013 in Utrecht, the Netherlands. The articles included were selected by external reviewers using a double blind process.
Timor-Leste has made impressive progress since its historic achievement of independence in 2002. From the instability that blighted its early years, the fledgling democratic country has achieved strong economic growth and a gradual reinstatement of essential social services. A decade on in 2012, Presidential and Parliamentary elections produced smooth political transitions and the extended UN peacekeeping presence in the country came to an end. But significant challenges remain. This book, a product of the inaugural Timor-Leste Update held at The Australian National University in 2013 to mark the end of Timor-Leste’s first decade as a new nation, brings together a vibrant collection of pap...
This book presents a state-of-the-art account of the recent developments and needs for project management in developing countries. It adds to the current state of knowledge on project management in general by capturing current trends, how they widen the content and scope of the field, and why there is a need for a specialist body of knowledge for developing countries. Eminent experts in this domain address the specific nature and demands of project management in developing countries, in the context of its scope and priorities, and discuss the relationships between this emerging field and established bodies of knowledge. The book also addresses the future of project management in developing countries and how this might influence mainstream project management. This important book will be an essential reference for practitioners, students, researchers and policymakers engaged in how to improve the effectiveness and efficiency of project management in developing countries.
This book is a history of the struggle for independence after East Timor was invaded by Indonesia in 1975. The occupation, which lasted 24 years, was immediately resisted through guerrilla warfare and clandestine resistance. A continuum of effort between the armed freedom fighters in the mountains, the resilience of urban supporters, and international activism and support eventually brought about liberation in September 1999. Given that the Timor rebels did not have a land border with a friendly state, had no external supplier of weapons and no liberated area in which to recover between guerrilla operations, their successful resistance is unique in the history of guerrilla warfare and indepe...
This report provides an overview of the economic and institutional developments in East Timor up to September 1999 and the immediate impact of the violent events that followed the August 30, 1999 referendum to decide East Timor's future status. The report presents the key elements of the strategy recommended by IMF staff to the United Nations Transitional Administration in East Timor (UNTAET) to rebuild the institutions needed to support economic activity and public administration, including external financing requirements, technical assistance, and macroeconomic management training needs. Finally, the report assesses implementation of the strategy and discusses the steps that should be taken to ensure that the strategy will help East Timor to prepare to face future challenges.
This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.
Quantitative Structure-Activity Relationship (QSAR) is a field where true multidisciplinary approaches are being used. This volume titled Recent Trends on QSAR in the Pharmaceutical Perceptions offers an overview on the latest advancements in the field.
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial phys...
The Dynamics of Transitional Justice draws on the case of East Timor in order to reassess how internationally-sponsored transitional justice mechanisms actually play out at the local level.