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72nd Annual Meeting of the Italian Society of Physiology: New Perspectives in Physiological Research
The 72nd Meeting of the Italian Society of Physiology (SIF) gathers scientists from universities and institutes across Europe and offers a platform for discussing the most exciting developments in the areas of basic and translational physiology. This Frontiers Research Topic will collect varied contributions from original research to review articles from SIF participants covering key achievements and latest advancements in the field of physiology. This collection is led by Guest Editors Prof. Giovanna Valenti, Prof. Andrea Gerbino and Prof. Grazia Tamma from Università degli Studi di Bari Aldo Moro and Prof. Fiorenzo Conti from Università Politecnica delle Marche, Ancona, Italy.
Pazze di Lui - Mad for Him: Hagiographic Stereotypes, Mental Disturbances and Anthropological Implications of Female Saintliness in Italy and Abroad from the 13th to the 20th Century
The aim of this book is to investigate the delicate relationship between female sanctity and madness, in a time-frame extending from medieval until contemporary times. Constellated by visions, ecstatic raptures, morbid rituals, stigmata and obsessions, the complex phenomenology of female mysticism appears in fact to be articulated and polymorphous, traversed by 'representations' that it seems possible to link to the wide spectrum of mental disorders, as well to the hagiographic stereotypes and anthropological implications. Male and female scholars from different disciplines (from history to philology, from anthropology to art history, from theology to literary criticism, from psychiatry to psychoanalysis) try to outline a thematic and problematic itinerary, intended to examine, step by step, potential pathological aspects and contexts of reference for the purpose of attempting to reconstruct the complex evolutionary trajectory of female mystical language.
Epilepsy and Neurodevelopmental Diseases
This topic has been realized in collaboration with Dr. Gabriele Ruffolo, Post Doctoral Researcher at the University of Rome (Sapienza) (ORCID ID: 0000-0002-6554-5496).
Excitatory Amino Acids and the Cerebral Cortex
It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years.
The First Outstanding 50 Years of “Università Politecnica delle Marche”
The book describes the significant multidisciplinary research findings at the Università Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today’s fast-growing, global society and the changes it has caused. It also discusses solutions to improve the wellbeing of human beings. The book covers the main research achievements in the various disciplines of the life sciences, and includes chapters that highlight mechanisms relevant to all aspects of human diseases, the molecular, cellular, and functional basis of therapy, and its translation into the management of people’s health needs. It also describes research on tradition...
Building up the inhibitory synapse
Fast inhibitory transmission exerts a powerful control on neuronal excitability and network oscillations thought to be associated with high cognitive functions. An alteration of inhibitory signaling is associated with major neurological and psychiatric disorders including epilepsy. Once released from presynaptic nerve terminals, GABA and glycine cross the synaptic cleft and bind to postsynaptic receptors localized in precise apposition to presynaptic release sites. The functional organization of inhibitory synapses consists in a dynamic process which relies on a number of highly specialized proteins that ensure the correct targeting, clustering, stabilization and subsequent fate of synaptic ...
Excitatory Amino Acids and the Cerebral Cortex
The thirty original contributions in this book provide an up-to-date, interdisciplinary account of current research activity in all aspects of excitatory amino acid transmitters, particularly glutamate and aspartate, in the context of the structure and function of the cerebral cortex in health and in disease.It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many ...
Neuroanatomy for the XXIst Century
An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the n...
The Functional Roles of Glial Cells in Health and Disease
Thirty-five years ago, when Stephen Kuffler and his colleagues at Harvard initiated a new era of research on the properties and functions of neuroglial cells, very few neuro scientists were impressed at the time with the hypothesis that neuroglial cells could have another, though more subtle, role to play in the nervous system than to provide static support to neurons. Today, very few neuroscientists are unaware of the fact that multiple interactions between neurons and glial cells have been described, and that they consti tute the basis for understanding the function and the pathology of the nervous system. Glial cells outnumber neurons and make up about one-half of the bulk of the nervous system. They are divided into two major classes: first, the macroglia, which include astrocytes and oligodendrocytes in the central nervous system, and the Schwann cells in the peripheral nervous system; and second, the microglial cells. These different classes of glial cells have different functions and contribute in different ways in the devel opment, function, and the pathology of the nervous system.
