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Erythropoietic Stimulating Agents
The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase half-life of erythropoietin (EPO), finding different routes of administration and new ESA or modified EPO molecules. Scientific literature presents evidence that EPO has other effects beyond erythropoietic stimulation. These pleiotropic effects of EPO appear to result from the existence of two different EPO receptors (EPOR) with different affinities for EPO. The discovery of new EPO actions beyond the hematopoietic system has opened a new field of investigation with these agents. Several molecul...
Biomarkers of Cardiometabolic Risk, Inflammation and Disease
This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Risk, Inflammation and Disease is aimed at doctors specializing in internal medicine, neurology, cardiology, rheumatology, nephrology or endocrinology and will also be of interest to GPs, trainee doctors and clinical and basic researchers working on cardiovascular and autoimmune disorders.
Hypoxia and Human Diseases
This book contains a total of 21 chapters, each of which was written by experts in the corresponding field. The objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions in the detection, recognition, and management of hypoxia-related disorders. This collection of articles provides a clear update in the area of hypoxia research for biomedical researchers, medical students, nurse practitioners, and practicing clinicians in the fields of high altitude biology, cardiovascular biology and medicine, tumor oncology, obstetrics, pediatrics, and orthodontics and for others who may be interested in hypoxia.
Oxidative Stress Revisited - Major Role in Vascular Diseases
Oxidative stress is an underlying factor in health and disease. Reactive oxygen species are produced as a result of normal cellular metabolism. The subsequent altered redox state between the formation and the neutralization of pro-oxidants results in their increased levels and therefore leads to cellular damage. Different research disciplines have increased our knowledge of the importance of this cell redox status and the recognition of oxidative stress as a process with implications for many pathophysiological states. Genetic and environmental factors, nutrition and lifestyle may indicate a pro-oxidative and pro-inflammatory state, linked to alterations in cellular structure and function. O...
Psychoanalysis and the Global
Psychoanalysis and the GlObal is about the hole at the heart of the "glObal," meaning the instability and indecipherability that lies at the hub of globalization. The contributors use psychoanalysis to expose the unconscious desires, excesses, and antagonisms that accompany the world of economic flows, cultural circulation, and sociopolitical change. Unlike the mainstream discourse of globalization, which most often assumes unencumbered movement across borders, these contributors uncover what Lacan calls "the Real" of the glObal--its rifts, gaps, exceptions, and contradictions. Psychoanalysis and the GlObal adopts a psychoanalytic lens to highlight the unconscious circuits of enjoyment, raci...
Immunometabolism: Bridging the Gap Between Immunology and Nutrition
It is common ground that all cells require nutrients to develop, differentiate, and maintain their inherent activities. However, the idea that cells can rapidly alter their metabolism to perform specific functions under the pressure of different microenvironments was just brought to the light. These changes are particularly important for immune cells, as they need to respond quickly to opportunistic pathogens or tissue damage and prevent their spread. The field that investigates the interplay between immunology and metabolism is so-called immunometabolism and has supported the hypothesis that all diseases have a metabolic aspect.
Forensic Medicine
Forensic medicine is a continuously evolving science that is constantly being updated and improved, not only as a result of technological and scientific advances (which bring almost immediate repercussions) but also because of developments in the social and legal spheres. This book contains innovative perspectives and approaches to classic topics and problems in forensic medicine, offering reflections about the potential and limits of emerging areas in forensic expert research; it transmits the experience of some countries in the domain of cutting-edge expert intervention, and shows how research in other fields of knowledge may have very relevant implications for this practice.
Ambiente e sociedade
Os textos constituintes deste livro tratam de temáticas que examinam partes da realidade goiana pelas quais os autores elegem problemáticas traduzidas como condicionalidades e potencialidades do cerrado brasileiro. A obra compreende resultados de pesquisas num quadro de questões sociais declaradas por aspectos políticos, econômicos e culturais importantes e, por questões ambientais, assentadas na investigação de aspectos ecológicos, geotecnológicos e biológicos, que contribuem para a discussão e reflexão crítico-científicas. Nessa perspectiva, ampliam-se as possibilidades da ética da liberdade científica aliada à responsabilidade ética na discussão das diversidades e adversidades que caracterizam o meio natural e sua constante transformação pela interveniência do homem.
