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The Marathon of the Messenger
The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to ...
Multi-Pronged Omics Technologies to Understand COVID-19
"COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics tec...
Application of Antigen Cross-Presentation Research into Patient Care
The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations,...
Lab On A Chip
What Is Lab on a Chip A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (mTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids. However, strictly regarded "lab-on-a-chip" indicates generally the scaling of single or multiple lab processes down to chip-format, whereas "mTAS"...
Çip Üzerinde Laboratuvar
Çipte Lab Nedir? Çip üzerinde laboratuvar (LOC), otomasyon ve yüksek verimli tarama elde etmek için bir veya birkaç laboratuvar işlevini yalnızca milimetre ila birkaç santimetrekarelik tek bir entegre devre üzerinde entegre eden bir cihazdır. LOC'ler, piko litreden daha düşük olan son derece küçük sıvı hacimlerini işleyebilir. Çip üzerinde laboratuvar cihazları, mikroelektromekanik sistemler (MEMS) cihazlarının bir alt kümesidir ve bazen "mikro toplam analiz sistemleri" (μTAS) olarak adlandırılır. LOC'ler mikroakışkanları, fiziği, manipülasyonu ve çok az miktarda sıvının çalışmasını kullanabilir. Bununla birlikte, kesin olarak kabul edilen "çip ü...
ラボオンチップ
ラボオンチップとは ラボオンチップ(LOC)は、1つまたは複数のラボ機能をわずか数ミリメートルから数平方センチメートルの単一の集積回路に統合して、自動化とハイスループットスクリーニングを実現するデバイスです。 LOCは、ピコリットル未満までの非常に少量の液体を処理できます。ラボオンチップデバイスは、微小電気機械システム(MEMS)デバイスのサブセットであり、「マイクロトータル分析システム」(µ TAS)と呼ばれることもあります。 LOCは、マイクロフルイディクス、物理学、操作、および微量の流体の研...
Laboratoire Sur Puce
Qu'est-ce qu'un laboratoire sur puce Un laboratoire sur puce (LOC) est un dispositif qui intègre une ou plusieurs fonctions de laboratoire sur un seul circuit intégré de seulement quelques millimètres à quelques centimètres carrés pour réaliser l'automatisation et le criblage à haut débit. Les LOC peuvent gérer des volumes de fluides extrêmement petits jusqu'à moins de pico-litres. Les dispositifs de laboratoire sur puce sont un sous-ensemble de dispositifs de systèmes microélectromécaniques (MEMS) et parfois appelés "systèmes d'analyse micro totale" (μTAS). Les LOC peuvent utiliser la microfluidique, la physique, la manipulation et l'étude de quantités infimes de fluide...
Laboratorio Su Chip
Cos'è Lab on a Chip Un lab-on-a-chip (LOC) è un dispositivo che integra una o più funzioni di laboratorio su un unico circuito integrato da pochi millimetri a pochi centimetri quadrati per ottenere l'automazione e lo screening ad alto rendimento. I LOC possono gestire volumi di fluido estremamente piccoli fino a meno di pico-litri. I dispositivi Lab-on-a-chip sono un sottoinsieme di dispositivi di sistemi microelettromeccanici (MEMS) e talvolta chiamati "sistemi di analisi micro totale" (μTAS). I LOC possono utilizzare la microfluidica, la fisica, la manipolazione e lo studio di piccole quantità di fluidi. Tuttavia, "lab-on-a-chip" strettamente considerato indica generalmente il ridimen...
Labor Auf Einem Chip
Was ist Lab-on-a-Chip Ein Lab-on-a-Chip (LOC) ist ein Gerät, das eine oder mehrere Laborfunktionen auf einer einzigen integrierten Schaltung von nur Millimetern bis wenigen Quadratzentimetern integriert, um Automatisierung und Hochdurchsatz-Screening zu erreichen. LOCs können extrem kleine Flüssigkeitsvolumina bis zu weniger als Picoliter handhaben. Lab-on-a-Chip-Geräte sind eine Untergruppe von mikroelektromechanischen Systemen (MEMS) und werden manchmal als "Mikro-Gesamtanalysesysteme" (μTAS) bezeichnet. LOCs können Mikrofluidik, die Physik, Manipulation und Untersuchung winziger Flüssigkeitsmengen verwenden. Streng genommen bezeichnet "Lab-on-a-Chip" jedoch allgemein die Skalierung...
