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When the cast and crew of reality TV show 'SeaLife' land on picturesque, unexplored Henders Island it's a ratings bonanza. But they're blissfully unaware that the decisions they make there will shape the fate of mankind. They quickly discover, however, that the island is seething with danger.
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
The first monograph on the "godfather of streetwear," this book pays homage to Hiroshi Fujiwara's influence on contemporary fashion, music, and design. The most comprehensive book devoted to the extensive work of Hiroshi Fujiwara-a pioneer in streetwear, music, and art, and the ultimate arbiter of cool. Known internationally as one of the founding fathers of Tokyo's Harajuku scene, Fujiwara exerts a disproportionate influence over contemporary design culture. Having collaborated with the likes of Malcolm McLaren and Vivienne Westwood as a teenager in the early 1980s, he merged a seminal interest in punk with hip-hop and skate culture to become one of Japan's principal tastemakers. A musician...
The universe may well have begun with an immense act of fragmentation, "the big bang," that sent particles flying in all directions to perform spectacular acts of creation and destruction. The fragment, volatile and unpredictable, is not simply the static part of a once-whole thing but itself something in motion. Drawing upon art history, archaeology, literature, numismatics, philosophy, and film, this book explores the significance of the fragment and addresses the powerful drives that have impelled it into the cultural mainstream. Book jacket.
The continuing adventures of Hiroshi Fujiwara, "godfather of streetwear." Commanding the hothouse environment of Harajuku, the street fashion and culture district of Tokyo, Hiroshi Fujiwara is recognized the world over as a pioneer in streetwear, music, and art and is the ultimate arbiter of cool. Known internationally as one of the founding fathers of the 1990s Tokyo scene, Fujiwara exerts a disproportionate influence over contemporary design culture. With recent and highly successful collaborations with Louis Vuitton and Moncler, and with his mainstay work at Nike and Medicom, Fujiwara refines an aesthetic immersed in punk, hip-hop, and skate culture and translates it into pure luxury. A m...
For fans of The Hunger Games, Battlestar Galactica, and Blade Runner comes the first book in the Partials Sequence, a fast-paced, action-packed, and riveting sci-fi teen series, by acclaimed author Dan Wells. Humanity is all but extinguished after a war with Partials—engineered organic beings identical to humans—has decimated the population. Reduced to only tens of thousands by a weaponized virus to which only a fraction of humanity is immune, the survivors in North America have huddled together on Long Island. But sixteen-year-old Kira is determined to find a solution. As she tries desperately to save what is left of her race, she discovers that that the survival of both humans and Part...
From the award-winning, bestselling author of Addition and Nine Days, a superbly crafted and captivating literary mystery about a lost book and a secret love.
Taking as its starting point four contemporary visual artists whose work utilizes the conventions of museum display and collecting practices, Memory Fragments examines how these artists have reconfigured dominant representations of Australian history and identity, including viewpoints often marginalized by gender and race. Echoing Walter Benjamin's reflections on history and time, this interdisciplinary volume will be of interest to scholars working in the arts as well as modern and postmodern cultural studies.
This monograph is an interdisciplinary study of the concept of 'fragment' in literature and in critical and literary theory. It discusses the fragment's performativity and function within a historical perspective, stretching from Heraclitus, via the German Romantics and European writers of the Modernist period, to American postmodern manifestations of the fragment. This is the first history of the fragment to appear in English, and it is also the first attempt at producing a consistent taxonomy of literary and critical fragments. The fragments are categorised according to function, not author intention, and the study addresses a number of questions: What constitutes the fragment, when the fr...
Chase wishes he could remember the events of his accident, but when the memories begin to come back in his dreams, Chase must face the reality of his past and finally deal with the part he played in the tragic event.