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Osteoarthritis, Inflammation and Degradation
Osteoarthritis is a public health issue due to its impact in term of handicap. Regarded as a multi-factorial disease, mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. This book helps readers understand the secrets of this disease.
IL-1 Inhibition
This special article collection of Frontiers in Pharmacology includes reviews and original articles on different aspects of IL-1 inhibition. Since the time IL-1 and its natural antagonist IL-1Ra have been discovered, specific IL-1 targeted therapies have been developed to cure an increasing number of diseases. The purpose of this Research Topic is to provide an overview of the different clinical uses of IL-1 blockade and new insights in basic research issues.
10 Years of Inflammation Pharmacology
The past and future of inflammatory pharmacology research: a hot topic in health and disease Inflammation is a physiological response to a traumatic injury, bacterial, or viral infection. However, if not appropriately controlled, it contributes to a long list of diseases, including asthma, atherosclerosis, multiple sclerosis, arthritis, and cancer. Different are the types of inflammatory responses. Acute inflammation is an immediate body response to the cellular damage induced by pathogens, noxious stimuli, or physical injury – it is a short-term response resulting in healing via time-dependent changes of leukocyte functions. First, a leukocytes infiltration happens within the damaged regi...
Synovial Fluid Analysis and The Evaluation of Patients With Arthritis
This book reviews the major components of synovial fluid analysis, with an emphasis on crystal recognition. Synovial fluid analysis is the required gold standard test for the definitive diagnosis of septic and crystal induced arthritis, the most frequent causes of acute inflammatory arthritis. Synovial fluid is obtained routinely from patients with acute arthritis by clinicians in many specialties. Fluids are sent to the clinical pathology and microbiology laboratories for analysis, but are also frequently examined directly by rheumatologists and others for the presence of crystals. Competency in synovial fluid crystal analysis is a requirement for all graduating rheumatology fellows in the ...
Game of Love in Sermoneta
Cultural Association ""From Ischia The Art - DILA"" GAME OF LOVE IN SERMONETA by ANGELA MARIA TIBERI Vice President of the Association New Cenacle of Poetry of ApriliaPREFACE Entering in the world of the writer Angela Maria Tiberi and how to desecrate a tabernacle and lay bare her thoughts, her heart, her soul. Her world is inner made of dreamed and realistic relationships where passion and love intertwine to sciorination a great connection from she is lived and then lost in the street we do not know how and why. Her prose and her poems gather in a whirlwind of expressive desires that can never be reached for a great, timeless but unambiguous love. The poetics of Angela Maria Tiberi is not recommended to all those who have cold hearts escaped the sense of love. Failing to make it their own, they would think, foolishly, that these are utopian transpositions in verses of obsolete ideals, without realizing that the real ""old"" are only those who no longer know how to believe in love. Bruno Mancini
Regulatory T cells and Autoimmune Diseases
Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a mus...
Trieste
In Italy, an elderly mother awaits a reunion with the son stolen from her by the Nazis—“A darkly hypnotic kaleidoscope of a book” (The Jewish Daily Forward). Haya Tedeschi sits alone in Gorizia, in northeastern Italy, surrounded by a basket of photographs and newspaper clippings. Now an old woman, she waits to be reunited after sixty-two years with her son, fathered by an SS officer and stolen from her by the German authorities as part of Himmler’s clandestine Lebensborn project. Tedeschi reflects on her Catholicized Jewish family’s experiences, in a narrative that deals unsparingly with the massacre of Italian Jews in the concentration camps of Trieste. Her obsessive search for her son leads her to photographs, maps, and fragments of verse, to testimonies from the Nuremberg trials and interviews with second-generation Jews, and to eyewitness accounts of atrocities that took place on her doorstep. From this broad collage of material and memory arises the staggering chronicle of Nazi occupation in northern Italy that “explores the 20th century’s darkest chapter in an original way . . . an exceptional reading experience” (Minneapolis Star-Tribune).
Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses
Nano- and microparticles including crystals, synthetic biomaterials, misfolded proteins or environmental particulates are involved in a wide range of biological processes and diseases. They may present as intrinsic or environmental toxins but may also be applied intentionally, e.g. as immune adjuvants, drug carriers or ion exchangers. The discovery that a wide range of nano- and microparticles share the capacity to induce IL-1β secretion via activation of the NLRP3 inflammasome in dendritic cells and macrophages has led to the hypothesis that nano- and microparticles may contribute in a uniform mechanistic manner to different disease entities. Other molecular mechanisms triggered by a range...
