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The Cancer Degradome
This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.
The Spectrum of Bronchial Infection
Lower respiratory tract infections are one the most frequent causes of medical consultation in primary care. They are also one of the main causes of emergency visits and hospital admissions. The majority of these infections occur in the bronchial tree and include a large spectrum of aetiologies and clinical manifestations, from mild acute bronchitis to severe bronchiectasis and exacerbations of chronic obstructive pulmonary disease. In this Monograph, a series of prestigious researchers and clinicians provide an overview of the advances in the pathogenesis, manifestations and new approaches to treatment of bronchial infection in a wide variety of clinical scenarios. This book offers the reader the best existing scientific evidence that can be applied to the care of patients with any kind of bronchial infection.
General and Molecular Pharmacology
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
World Clinics: Pulmonary & Critical Care Medicine - Chronic Obstructive Pulmonary Disease
Part of the World Clinics series, this book is the second volume of the pulmonary and critical care medicine manuals and focuses on chronic obstructive pulmonary disease (COPD). The book begins with the epidemiology and pathophysiology of COPD, followed by chapters covering topics in the diagnosis and management of the disease, including acute exacerbations, imaging, biomarkers, oxygen therapy and vascular dysfunction. The final sections present a complete review of pulmonary disease and rehabilitation. This new volume includes numerous images, illustrations and tables to enhance the text. The previous volume in this series, Pneumonias, published in 2012. Key points Second volume covering chronic obstructive pulmonary disease (COPD) Part of the World Clinics: Pulmonary and Critical Care Medicine series Includes nearly 100 images, illustrations and tables Volume One published in 2012
Oxford Textbook of Critical Care
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summ...
Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Current Topics in Cellular Regulation
Current Topics in Cellular Regulation, Volume 19 analyzes the advances in the general area of cellular regulation. This book discusses the evidence indicating that synthesis of the histidine enzymes is regulated and drugs affecting ribonucleotide reductase. The analogy principle in comparative biochemistry of allosteric regulation of metabolism, steady-state model of glucose metabolism in adipose tissue, and sensitivity of enzyme activity to changing ion concentrations are also elaborated. This publication likewise covers the cAMP-dependent protein kinases of nervous tissue and amino acid sequences of IGF I and II. This volume is a good reference for biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.
Community-Acquired Pneumonia
Community-acquired pneumonia remains the leading cause of hospitalisation for infectious disease in Europe, and a major cause of morbidity and mortality. This issue of the European Respiratory Monograph brings together leading experts in pulmonology, infectious diseases and critical care from around the world to present the most recent advances in the management of community-acquired pneumonia. It provides a comprehensive overview of the disease, including chapters on microbiology, pathophysiology, antibiotic therapy and prevention, along with hot topics such as viral pneumonias and pneumonia associated with inhaled corticosteroids.
Chlamydia pneumoniae
Chlamydia pneumoniae is a bacteria that is most commonly known for causing colds and pneumonia. However, researchers have recently found a link between C. pneumoniae and atherosclerosis, a clogging of the arteries that causes heart attack and stroke. In addition, ongoing research is showing that certain strains may play a role in asthma, multiple sclerosis, Alzheimer's disease, and arthritis. This volume, part of the Infectious Agents and Pathogenesis series, is a complete portrait of C. pneumoniae and what is currently known about it.
Respiratory Infections in Allergy and Asthma
This reference presents investigations into the role of respiratory infections in protecting against allergy and asthma development, the activation of airway inflammation, and exacerbations of asthma--exploring cellular and molecular mechanisms, as well as factors including genetics, the environment, and allergen exposure.
