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This detailed volume explores contemporary techniques in mass spectrometry-based proteomics. After covering overall proteome coverage and the cellular surfaceome, the book delves into proximity-induced biotinylation, abduction of protein complexes in viral-like particles, and thermal proteome profiling, as well as protocols for identifying protein N-terminal acetylation, protein processing by proteases, protein N-glycosylation, and protein phosphorylation. The book also collects chapters on automated preparation of clinical samples, the analysis of formalin-fixed paraffin-embedded samples, protocols for the isolation of extracellular vesicles and for the monitoring of selected protein modifi...
In the tradition of The Return of Martin Guerre and The Great Cat Massacre, Miracles at the Jesus Oak is a rich, evocative journey into the past and the extraordinary events that transformed the lives of ordinary people. In the musty archive of a Belgian abbey, historian Craig Harline happened upon a vast collection of documents written in the seventeenth century by people who claimed to have experienced miracles and wonders. In Miracles at the Jesus Oak, Harline recasts these testimonies into engaging vignettes that open a window onto the believers, unbelievers, and religious movements of Catholic Europe in the Age of Reformation. Written with grace and charm, Miracles at the Jesus Oak is popular history at its most informative and enlightening.
This second edition volume discusses the latest techniques and protocols used in the field that were not covered in the previous edition. The chapters in this book are organized into five parts. Part One looks at transcriptomic analyses and Part Two covers DNA replication and protein/DNA interactions. Part Three discusses translation dynamics, protein complexes, and proteomics. Part Four looks at genotypic screens and phenotypic profiling, and Part Five explores in silico integration of functional genomics data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary material and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Yeast Functional Genomics: Methods and Protocols, Second Edition is a valuable resource for all researchers interested in learning more about the evolving field of yeast. Chapters 1, 9, 16, 20, 22, 24, and 25 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Snake Music is a coming-of-age story set in the 1940s and 1950s in an inner-city Catholic neighborhood of Detroit, Michigan. The author, J. Patrick Reilly, describes his struggles to cope with his mother's near-fatal descent into mental illness, his father's alcoholism and early death, his family's desperate financial straits, and a devastating accident that crippled him for several years. In the midst of these challenges, Snake Music shows the redeeming power of a loving mother, good humor, and a love for music. Reilly reveals an old and terrible family secret and its multigenerational consequences, while telling his own story through the eyes of the boy he was at each stage of his memoir. Snake Music makes the reader laugh out loud, and sometimes cry.
Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consens...
The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.