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Gene Mapping, Discovery, and Expression
Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific...
Red Cell Development
This compendium provides a concise and up-to-date assessment of critical recent issues related to erythroid biology. Developmental, epigenetic, methodological, biochemical, and clinical aspects are integrated to provide a powerful overview of their interrelationships and importance to the generation of the red cell. The excitement generated by these novel observations and the anticipation of future directions in studies of the red cell is a highlight of this volume. *The first comprehensive volume covering the breadth of the topic *The latest advancements that lead to novel directions in the study of red cells *An informative discussion of red cells as they relate to the essential oxygen-carrying component of the body
microRNAs in Development
This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. - Concentrates on microRNAs in development - Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA - With an international team of authors, this volume is a must-have addition for researchers and students alike
Modern Trends in Human Leukemia IX
This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Invertebrate and Vertebrate Eye Development
Vision is our primary sensory modality, and we are naturally curious as to how the visual system assembles. The visual system is in many ways remarkably simple, a repeating assemblage of neurons and support cells that parse the visual field through precision and redundancy. Through this simplicity the eye has often led the way in our exploration of how an organ is assembled. Eye development has therefore long been a favorite for exploring mechanisms of cell fate choice, patterning and cell signaling.This volume, which is part of the Current Topics in Developmental Biology series, highlights the exceptional advances over the past 20 years. Chapters emphasize our knowledge of transcription fac...
Understanding Genes And Gmos
The rapid progress in genomics and related technologies has increased interest in genetically modified organisms (GMOs). This concise and highly readable book equips the reader with essential information about what genes are, how they work, and how they can be modified and used in biotechnology. The book starts with a summary of the beginnings of life, the structure and components of living organisms, and an outline of genetic engineering.The coverage of human genetics spans race, human evolution and migration, the sex chromosomes, gene therapy, and forensic science. A separate chapter is devoted to the genetics and evolution of some of the major disease-causing organisms. On environmental genetics, the book considers the risks of releasing agricultural GM plants, as well as bioremediation and metal extraction by GM plants. Applications of genetic modification in agriculture — pest-resistant plants, herbicide resistance, and improved foods — are presented as part of a discussion on sustainable agriculture to emphasize the role played by GM plants in relation to chemicals, analytic techniques, and organic farming.
The Paradox of Scientific Authority
Assessing the influence of scientific advice in societies that increasingly question scientific authority and expertise. Today, scientific advice is asked for (and given) on questions ranging from stem-cell research to genetically modified food. And yet it often seems that the more urgently scientific advice is solicited, the more vigorously scientific authority is questioned by policy makers, stakeholders, and citizens. This book examines a paradox: how scientific advice can be influential in society even when the status of science and scientists seems to be at a low ebb. The authors do this by means of an ethnographic study of the creation of scientific authority at one of the key sites fo...
How Life Works
A cutting-edge new vision of biology that will revise our concept of what life itself is, how to enhance it, and what possibilities it offers. Biology is undergoing a quiet but profound transformation. Several aspects of the standard picture of how life works—the idea of the genome as a blueprint, of genes as instructions for building an organism, of proteins as precisely tailored molecular machines, of cells as entities with fixed identities, and more—have been exposed as incomplete, misleading, or wrong. In How Life Works, Philip Ball explores the new biology, revealing life to be a far richer, more ingenious affair than we had guessed. Ball explains that there is no unique place to lo...
Blood Cell Biochemistry
Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express ing adenosine deaminase (the defective enzyme in p...
Transcriptional Switches During Development
This new volume in the Current Topics in Developmental Biology series concentrates on transcriptional switches during development. It includes chapters on such topics as muscle diversity, transcriptional response to genome structural variation, and the temporal gene network in Drosophila neural stem cells. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on transcriptional switches during development Includes chapters on such topics as muscle diversity, transcriptional response to genome structural variation, and the temporal gene network in Drosophila neural stem cells With an international team of authors, this volume is a must-have addition for researchers and students alike
