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Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever. The text is written with a wide audience in mind and to be readily understandable for clinicians as well as biomedical researchers and pharmacologists alike. The content is up to date and includes the latest results of clinical and academic research, with a balanced view on the disputed properties of this famous drug.
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This book is a highly readable and entertaining account of the co-evolution of the patent system and the life science industries since the mid-19th century. The pharmaceutical industries have their origins in advances in synthetic chemistry and in natural products research. Both approaches to drug discovery and business have shaped patent law, as have the lobbying activities of the firms involved and their supporters in the legal profession. In turn, patent law has impacted on the life science industries. Compared to the first edition, which told this story for the first time, the present edition focuses more on specific businesses, products and technologies, including Bayer, Pfizer, GlaxoSmithKline, aspirin, penicillin, monoclonal antibodies and polymerase chain reaction. Another difference is that this second edition also looks into the future, addressing new areas such as systems biology, stem cell research, and synthetic biology, which promises to enable scientists to “invent” life forms from scratch.
"This is one of the most important studies of nineteenth century chemistry produced during the past two decades. Building on his equally important earlier book . . . this work will establish Rocke as the leading scholar in this field."--Frederic L. Holmes, Yale University "With this work, Rocke has become the leading authority on German chemistry in the first two-thirds of the nineteenth century."--Kathryn M. Olesko, Georgetown University
This riveting book takes the reader around the globe and through the centuries to discover how different cultures have sought to combat and treat physical pain. With colorful stories and sometimes frightening anecdotes, Dr. Thomas Dormandy describes a checkered progression of breakthroughs, haphazard experiments, ignorant attitudes, and surprising developments in human efforts to control pain. Attitudes toward pain and its perception have changed, as have the means of pain relief and scientific understanding. Dr. Dormandy offers a thoroughly fascinating, multi-cultural history that culminates with a discussion of today’s successes--and failures--in the struggle against pain. The book’s exploration is fused with accounts of the development of specific methods of pain relief, including the use of alcohol, plants, hypnosis, religious faith, stoic attitudes, local anesthesia, general anesthesia, and modern analgesics. Dr. Dormandy also looks at the most recent advances in pain clinics and palliative care for patients with terminal disease as well as the prospects for loosening pain’s grip in the future.
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Fred Aftalion's international perspective of the history of chemistry integrates the story of chemical science with that of chemical industry. This new edition includes events from 1990 to 2000, when major companies began selling off their divisions, seeking to specialize in a particular business. Aftalion explores the pitfalls these companies encountered as well as the successes of "contrarians"--those companies that remained broad and diversified. He uses BASF, Dow, and Bayer as examples of true contrarians.