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Translational Research Methods in Neurodevelopmental Disorders
This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experiment...
Innovative approaches and therapeutic perspectives for early-onset neurodevelopmental disorders: from bench to bedside.
In partnership with the Jacques Monod Conference “Genetics, environment, signaling & synaptic plasticity in developmental brain disorders: from bench to bedside", the Frontiers in Neuroscience Journal announces an article collection that will highlight cutting-edge research presented at the 2022 meeting from Monday 11th Apr - Friday 15th Apr in Roscoff (Brittany). Neurodevelopmental Disorders (NDDs) are a highly heterogeneous group of disorders with a prevalence of 3% of the worldwide population. These disorders include Intellectual Disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder, specific learning disorder, motor and language disorder, schizophren...
Existe-t-il des gènes du comportement?
Elle prend sous son charme tous les champs de la connaissance. Elle remet en question les règles de la morale en vigueur. Elle triomphe, elle séduit, elle colonise. Elle : la génétique. N’aurait-elle pas tendance à ratisser trop large ? Chaque comportement aurait ainsi son gène, chaque vice et chaque vertu, presque. Pour l’intempérance, nous aurions ainsi le choix avec les gènes de l’appétence pour l’alcool, le sucre ou le gras. Pour l’orgueil, il y aurait le gène de la dominance chez la souris… Qu’en est-il des maladies mentales, des déficits intellectuels et de la violence chez l’homme ? Et voilà trois ans, il a beaucoup été question du gène de l’infidélit...
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Transtorno do espectro autista: concepção atual e multidisciplinar na saúde
O livro “Transtorno do Espectro Autista: concepção atual e multidisciplinar na saúde”, que tive o prazer de organizar, trata-se de uma obra literária científica onde pudemos selecionar cuidadosamente os temas a serem publicados, baseados na própria ideia conceitual do livro, que seria uma abordagem multidisciplinar com informações atualizadas e recentes sobre o TEA. Longe de trazer soluções e respostas para todos os questionamentos e dúvidas sobre o TEA, este livro teve como objetivo abrir espaço para que a comunidade acadêmica dialogasse livremente com o tema, onde cada autor de capítulo, diante de sua expertise, pudesse compartilhar com os leitores informações que ajudassem a entender um pouco mais sobre o TEA e as pessoas com este transtorno.
