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Thrombosis in Clinical Practice
Designed for everyday use, primarily in the hospital setting, Thrombosis in Clinical Practice is a practical clinical reference to the management of thrombosis. The text provides a concise guide to the latest drugs and their applications and reviews appropriate therapeutic strategies for each of the most commonly-encountered clinical scenarios. Numerous flowcharts and checklists support and enhance the text, assisting the reader with case assessment and formulation of treatment plans. Copiously illustrated with tables, graphs, and charts, the book explains fundamental principles of etiology and mechanisms of drug action and includes the latest information on new agents and on-going trials.
Platelets
Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. - First edition won Best Book in Medical Science Award from the Association of American Publishers - Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias - A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references
Modern Transfusion Therapy
This two-volume text demonstrates the progress towards a better and more rational use of blood kproducts. The major topics of transfusion therapy are covered from both a laboratory and a clinical perspective. Discipline lines are crossed, involving such topics as biochemistry, hematology and infectiious disease. This reference serves as an important resource for clinicians involved in transfusion, blood bank personnel, and scientists working with the development of improved blood components.
Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology
The first invasive evaluation of cardiac arrhythmias in humans was performed in 1967 in Paris (Prof. P. Coumel) and Amsterdam (Prof. D. Durrer). This was the start of a rapid increase in our knowledge of the diagnosis, mechanism and treatment of cardiac arrhythmias. In that same year Prof. Hein J.J. Wellens became cardiologist in the Wilhelmina Gasthuis in Amsterdam. Initially in Amsterdam (1967-1977) and later on in Maastricht (from 1977), he was the driving force for many breakthroughs in clinical cardiac electrophysiology. With an active interplay between the knowledge derived from the 12-lead electrocardiogram and the recordings made with invasive electrophysiology, he composed new ideas...
Imagine Math
Imagine mathematics, imagine with the help of mathematics, imagine new worlds, new geometries, new forms. This book is intended to contribute to grasping how much that is interesting and new is happening in the relationships between mathematics, imagination and culture. With a look at the past, at figures and events, that help to understand the phenomena of today. It is no coincidence that this volume contains an homage to the great Italian artist of the 1700s, Andrea Pozzo, and his perspective views. Theatre, art and architecture are the topics of choice, along with music, literature and cinema. No less important are applications of mathematics to medicine and economics. The treatment is rigorous but captivating, detailed but full of evocations, an all-embracing look at the world of mathematics and culture
Evolution of Translational Omics
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Facts and Hopes in Thrombolysis in Acute Myocardial Infarction
It was a great pleasure for us to welcome so many experts from all over the world to our symposium in Aachen. We are also pleased - and you can attribute this to my own vanity - with the success and acceptance of the concept of myocardial reperfusion and revascularization - specifically selective intracoronary lysis followed either by PTCA or bypass surgery - which we have been pursuing since 1979. But after the dramatic immediate effects of the first attempts, which you have to experience yourself, we did not expect it to be any different. We decided against performing a randomized study in which every patient is catheterized, and thrombolytic therapy only given to some of the patients, for...
PTCA An Investigational Tool and a Non-Operative Treatment of Acute Ischemia
Obstruction of coronary blood flow and the resultant consequences are the center stage pathophysiologic events in cardiology today. The speculations of Jenner, Burns, Heberdin, McKenzie, Prinzmetal and many others had until now been left to observations of isolated tissue and intact animal experimentation. Only with the advent of Gruentzig's technique, which allowed us to 'work safely inside the coronary arteries' are we able to observe the effects of coronary occlusion in living conscious man. PTCA provides not only a therapeutic modality for non-operatively opening coronary obstructions, but has also provided the best model for studying the effects of acute ischemia on the heart. The proce...
Oxygen Transport to Tissue XXIV
This volume contains refereed manuscripts prepared from presentations made at the 2ih annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT). The meeting was held in Hanover, NH, USA, at Dartmouth Medical School, the 3rd oldest medical school in the USA. ISOTT attempts to produce high quality pUblications on cutting edge topics relating to oxygen in living systerns. The goal is to allow contributors to contribute original data, as with a main-stream journal article, but also to voice individual opinions and ideas in a more relaxed scientific forum. The meeting brought together an international group of scientists who share a common interest in the measurement and r...
