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The Peptides
The Peptides, Volume II: Synthesis, Occurrence, and Action of Biologically Active Polypeptides focuses on the synthesis of biologically active polypeptides and analogues. The publication first offers information on linear peptides and heterodetic cyclic peptides. Discussions focus on depsipeptides, polycyclic and monocyclic disulfides, naturally occurring biologically active peptides, glandular hormones, and tissue hormones. The text then ponders on homodetic cyclic peptides, including homodetic cyclic homomeric peptide antibiotics, polycyclic biologically active polypeptides, and homodetic cyclic heteromeric peptide antibiotics. The manuscript takes a look at the problems related with the synthesis of biologically active polypeptides, giving emphasis to a number of movements which elaborated on the matter and the advancements of preparative techniques and approaches leading to the purification of intermediates and end products. The publication is a valuable reference for researchers interested in the occurrence, synthesis, and action of biologically active polypeptides.
Early Modern European Diplomacy
New Diplomatic History has turned into one of the most dynamic and innovative areas of research – especially with regard to early modern history. It has shown that diplomacy was not as homogenous as previously thought. On the contrary, it was shaped by a multitude of actors, practices and places. The handbook aims to characterise these different manifestations of diplomacy and to contextualise them within ongoing scientific debates. It brings together scholars from different disciplines and historiographical traditions. The handbook deliberately focuses on European diplomacy – although non-European areas are taken into account for future research – in order to limit the framework and ensure precise definitions of diplomacy and its manifestations. This must be the prerequisite for potential future global historical perspectives including both the non-European and the European world.
Polyamines in Health and Nutrition
The importance of polyamines for all living cells has been recognized since spermine was discovered in human semen more than 300 years ago. Polyamine research intensified when analytical methods were developed for their determination, particularly in tissues and biological fluids. Discovering their close correlation with cancer, and that polyamine concentrations change during the cell cycle, gave reason for further research in this topic. Polyamines in Health and Nutrition concentrates on the direction of polyamine research which has the capacity to influence and benefit our health and which can explain some of the discrepancies and failures of earlier research. It is important to recognize the dietary contribution to the polyamine body pool and to investigate how the polyamine content of the diet can be changed, with the ultimate aim of using this information to improve our health.
Basic Epithelial Ion Transport Principles and Function
This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fu...
The Civil Service in Europe
This book opens an often nationally focused field of research to a transnational, common European debate. It addresses the ongoing transformation of the civil service, examining its evolving landscape across Europe and exploring the intricate web of historical, social, and political influences that are shaping its current state and setting the future direction. Written by experts from different European countries, this book offers a transnational and interdisciplinary perspective on the civil service by combining legal analysis with insights from public management, political science, and sociology. It addresses the growing complexity of public administration tasks and the increasing requirem...
