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Peripheral Neurons in Nociception
This book is a review of studies on the physiopharmacology of the peripheral fibres involved in nociception. It examines the substances that are directly or indirectly capable of modifying the activity of these fibres, paying special attention to the part played by physicochemical factors and the sympathetic nervous system. Drawing on the conclusions of eminent pharmacologists, the book not only considers fundamental aspects of the problem but also suggests approaches for research into developing new analgesic molecules. It will be of interest to researchers, pharmacologists, physiologists, physicians and the pharmaceutical industry.
Guilbaud
None
Somatosensory System
The waterproof sensory sheet covering the mammalian body has a rich afferent innervation which provides an abundance of complex information for use by the central nervous system often in conjunction with information from receptors in the joints. This book is an attempt to provide a systematic account of the way in which this somatosensory system works. The properties of the peripheral receptors have been debated in scientific terms for about a century and the resolu tion of the conflict in favour of the existence of 'specific' receptors for mechanical, thermal and noxious stimuli is reported and discussed in the opening chapters of the book. An awareness of this specificity has forced a re-c...
Phantom Pain
Phantom pain is an intriguing mystery that has captured the imagination of health care providers and the public alike. How is it possible to feel pain in a limb or some other body part that has been surgically removed? Phantom pain develops among people who have lost a limb or a breast or have had internal organs removed. It also occurs in people with totally transected spinal cords. Unfortunately, phantom pain is a medical night mare. Many of the people reporting phantom pain make dispropor tionately heavy use of the medical system because their severe pains are usually not treated successfully. The effect on quality of life can be devas tating. Phantom pain has been reported at least since...
Opioids II
This two-volume book provides the first comprehensive survey of opioid research, a field which has accumulated a tremendous amount of literature since the identification of opioid receptors and their endogenous ligands. In more than 60 chapters experts present state-of-the-art reviews of this fascinating field, the topics ranging from molecular biology to clinical applications. Part I covers the multiplicity of opioid receptors, the chemistry of opiates and opioid peptides as well as the neurophysiology of opioids. Part II reviews a broad spectrum of physiological and behavioral functions and pharmacological actions of opioids, together with their neuroendocrinology, opioid tolerance and dependence, concluding with pathophysiological aspects and clinical use.
Serotonin
The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonerg...
Forebrain Areas Involved in Pain Processing
Our knowledge of the brain and its structures -- such as the thalamus, hypothalamus and cortex -- has made great strides over the past 15 years. As in other fields, this progress has been due to studies based on a multidisciplinary approach combining modern and traditional investigative methods. The new knowledge has highlighted the part played by some fundamental structures in pain processing. This book reviews the data that has been acquired and the new perspectives it has opened up for studying how the brain processes pain, in both humans and animals. For neurologists, neurobiologists and neurosurgeons.
Compromise, Negotiation and Group Decision
Financial support from the following institutions, in addition to the personal contributions of the 200 parti cipants, made the conference an enjoyable event - Universite d' Aix-Narseille III - Centre National de la Recherche Scientifique - City of Aix-en-Provence - Faculte d'Economie Appliquee - G.R.A.S.C.E. Association Fran~aise de Science economique - Air France - Chambre de Commerce et d'Industrie de Marseille - Chambre Regionale de Commerce et d'Industrie (Provence - Alpes - Cote d'Azur - Corse) - Compagnie Fran~aise des Petroles - Conseil General des Bouches-du-Rhone - Conseil Regional (Provence - Alpes - Cote d'Azur) - Electricite de France - Societe Lyonnaise de Banque - Societe Nati...
Basal Ganglia and Thalamus in Health and Movement Disorders
This volume is comprised of the majority of lecture presentations and a few select posters presented at the International Workshop, "Basal Ganglia and Thalamus in Health and Movement Disorders," held in Moscow, Russia, on May 29-31, 2000. The International Committee responsible for organizing this workshop included Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of Medical Sciences, Mahlon DeLong, Chair, Department of Neurology, Emory University, Atlanta, USA, Alim Louis Benabid, Chief, Neurosurgery Service, University of Joseph Fourrier, Grenoble, France, and the two undersigned. The workshop was conceived out of a desire to provide a forum for discussions of both basal ganglia-and motor thalamus-related issues by bringing together basic scientists and clinicians representing different disciplines, research directions, and philosophies. The primary goals were to encourage an exchange of information and ideas in an informal environment, to stimulate integration of the data from different disciplines, and to identifY controversial issues and the most essential questions to be addressed in future research.
Annual Reports in Medicinal Chemistry
Praise for the Series:"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."--Enzymologia"This book is strongly recommended for researchers, teachers, students, administrators - in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inlusion in the scientist's personal library."--Journal of Medicinal Chemistry"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."--Norman Gilman, Hoffmann-La Roche, Inc, in the JOURNAL OF PHARMACEUTICAL SCIENCESAdvances in Medicinal Chemistry continues to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
