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Lecithin
Recently, there has been tremendous scientific interest in the role of phospholipids and particularly phosphatidylcholine (lecithin) in a variety of biological processes. These include the involvement of phosphatidylcholine in biological membranes, as a component of plasma lipoprotein, as a transporter of choline in the body, and also as a "reserve", and possibly only source of unesterified choline. Moreover, numerous clinical studies have recently been conducted, to evaluate the possible uses of externally supplied lecithin in the treatment of some intractible neuropsychiatric disorders (e.g. tardive dyski.nesia, Alzheimer's disease, etc.) and other conditions (e.g. hypercholesteremia). Res...
Ganglioside Structure, Function, and Biomedical Potential
This volume contains the proceedings of the symposium on "Ganglioside Structure, Function and Biomedical Potential" which was held at Parksville, Vancouver Island, B. C. , Canada on July 6-10, 1983. The symposium was organized ao a satellite to the ninth meeting of the International Society for Neurochemistry, held immediately afterward in Vancouver City, B. C. Close to 50 speakers from 9 countries presented papers on a wide range of topics on the ganglioside theme. These encompassed the many aspects of basic research that have evolved over the past half-century, as well as some newer topics relating to the biomedical potential of gangliosides as therapeutic agents. One of the purposes of th...
Plasticity and Regeneration of the Nervous System
Proceedings of the Third Conference of the Institute of Developmental Neuroscience and Aging, held in Torino, Italy, April 5-7, 1990
Biochemical Basis of Functional Neuroteratology
Biochemical Basis of Functional Neuroteratology
Machinery of the Mind
In the spring of 1987, I was in Havana, Cuba, where I was participating in planning a large-scale longitudinal study of the neurophysiological, neurochemical, and behavioral characteristics of cohorts of patients with cerebrovascular disease, depression, senile dementia, schizophrenia, or learning disabilities; and also part of this study were their first-degree blood relatives. This study was the outgrowth of a long-term project on the practical application of computer methods for the evaluation of brain electrical activity related to anatomical integrity, maturational development, and sensory, perceptual;ยท-and cognitive processes, especially in chil dren. For many years, that project had ...
Aging and Cell Function
The aging process, like most (all?) things in the universe, is a puzzle. It is such a fundamental occurrence, common to all living things, that it ironically may be the most complicated and perplexing puzzle to solve. There are, of course, puzzles sufficient in number to occupy all the scientists and philosophers who have ever lived a thousand times over. Yet what other phenomenon affects everyone of us as much as growing old? Curiosity about the ubiquity of aging as a phenomenon, boosted perhaps by an only natural fear of that same phenomenon as an undeniable manifes tation of our own mortality, has led to the compilation of data on the aging process, which have accumulated as rapidly as th...
Gangliosides and Neuronal Plasticity
This volume contains the Proceedings of the Meeting "Neuronal plasticity and gangliosides" which was held at Mantova, Italy, on May 29-31, 1985, as a satellite to the Tenth Meeting of the International Society for Neurochemistry, (Riva del Garda, Italy, May 19-24,1985). The Symposium took place in the "Teatro Bibiena", one of the oldest and most beautiful theatres in Italy, known for having been the place for some of the very first performances of W .A. Mozart. The number of registered participants in the Meeting was about 180 including 40 accor:Qpanying persons. The persons invited as Speakers or Chairmen of Colloquia and Workshops were 48. Eighteen countries were represented with the largest contingent coming from Italy, followed by Federal Republic of Germany, The United States, France and Great Britain. The Meeting was based on Colloquia, Workshops, Round Tables and Poster Sessions, with a total of 42 Lectures and 32 Poster presentations.
Alterations of Metabolites in the Nervous System
In neurosciences one may say, '"All roads lead to Rome. " It seems as though wherever one starts, the course of investigation leads to the same major ques tions about nervous system function and dysfunction. In thinking about what to write in this preface, it occurred to me that it might be best to deal with that with which I am most familiar and to trace to some extent my own '"road to Rome. '' As I look over my work of the last 37 years, it becomes clear to me that it can be epitomized as a search for patterns. What usually began as a single minded devotion to in-depth analysis of one or a small number of variables always has led to questions of how the results might relate to the whole li...
Progress in Medicinal Chemistry
Progress in Medicinal Chemistry
Chemical Factors in Neural Growth, Degeneration and Repair
This volume provides an up-to-date survey of current thinking concerning the actions of chemical factors in the regulation of neuronal behaviour under normal and pathological conditions. The book is divided into four sections, dealing with chemical factors involved with the formation of axon pathways, factors involved with neuronal survival and specialization during normal development, factors involved in normal maintenance and repair of adult neurons and, finally, factors that have been implicated as mediators of degenerative changes in neurological and neuropsychiatric disorders.
