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Metabolic Reprogramming
This volume provides state-of-the-art methods and protocols from researchers in the field of metabolism. Chapters guide readers through methodologies measuring different aspects of lipid metabolism, quantifying the amino acids, mitochondrial and intracellular by-products, detect enzyme and kinase activities, detecting a variety of metabolic pathways, and intracellular networks including nucleotide metabolism and the metabolic response to hypoxia and cytotoxic drugs. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Metabolic Reprogramming: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Peroxiporins
To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emit...
Self-Aware Computing Systems
This book provides formal and informal definitions and taxonomies for self-aware computing systems, and explains how self-aware computing relates to many existing subfields of computer science, especially software engineering. It describes architectures and algorithms for self-aware systems as well as the benefits and pitfalls of self-awareness, and reviews much of the latest relevant research across a wide array of disciplines, including open research challenges. The chapters of this book are organized into five parts: Introduction, System Architectures, Methods and Algorithms, Applications and Case Studies, and Outlook. Part I offers an introduction that defines self-aware computing system...
Nature and History in Modern Italy
Marco Armiero is Senior Researcher at the Italian National Research Council and Marie Curie Fellow at the Institute of Environmental Sciences and Technologies, Universitat Aut(noma de Barcelona. He has published extensively on-Italian environmental history and edited Views from the South: Environmental Stories from the Mediterranean World. --
Riflessi d’Oriente
Il volume illustra le esperienze di viaggio in Levante dei fiorentini Giovanni Mariti e Domenico Sestini tra il 1760 e il 1792. Da Cipro a Istanbul alla Mesopotamia, i resoconti restituiscono un’immagine vivace della realtà dell’Impero Ottomano, ricca di osservazioni naturalistiche e di una variegata panoramica di costumi, lingue e istituzioni, nonché su percorsi, economia e condizioni sanitarie delle regioni attraversate. Le numerose pubblicazioni a stampa che ne sortirono, quali i Viaggi per l’isola di Cipro e la Soria di Mariti (1769-1776) e il Viaggio da Costantinopoli a Bassora di Sestini (1786) conobbero notevole fortuna e furono tradotte in varie lingue. Il volume attesta l’appartenenza degli autori alla ‘Repubblica delle lettere’ e il crescente interesse per l’Islam e il mondo ottomano nel dibattito illuminista alle soglie della Rivoluzione francese.
