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Microarray Innovations
In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr
Biochips as Pathways to Drug Discovery
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as bioc
Systems Analytics and Integration of Big Omics Data
A “genotype" is essentially an organism's full hereditary information which is obtained from its parents. A "phenotype" is an organism's actual observed physical and behavioral properties. These may include traits such as morphology, size, height, eye color, metabolism, etc. One of the pressing challenges in computational and systems biology is genotype-to-phenotype prediction. This is challenging given the amount of data generated by modern Omics technologies. This “Big Data” is so large and complex that traditional data processing applications are not up to the task. Challenges arise in collection, analysis, mining, sharing, transfer, visualization, archiving, and integration of these data. In this Special Issue, there is a focus on the systems-level analysis of Omics data, recent developments in gene ontology annotation, and advances in biological pathways and network biology. The integration of Omics data with clinical and biomedical data using machine learning is explored. This Special Issue covers new methodologies in the context of gene–environment interactions, tissue-specific gene expression, and how external factors or host genetics impact the microbiome.
Environmental Contaminants and Endocrine Health
Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation ...
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on...
Smartphones for Chemical Analysis: From Proof-of-concept to Analytical Applications
Smartphones for Chemical Analysis: From Proof-of-Concept to Analytical Applications, Volume 101 in the Comprehensive Analytical Chemistry series, highlights new advances in this broadening field, with chaters that cover Smartphone-based assay benchmarking using traditional instrumental analysis, Smartphone-based water analysis, Sample preparation in smartphone-based analysis: Current status and challenges, Application of smartphone-based analysis in the medical field, Smartphone-based biosensors in the food analysis field, Bioreceptors for smartphone detection, Smartphone "anatomy": Features used for ubiquitous sensing, and much more. Additional chapters cover End-user integration for at-hom...
A Poison Like No Other
“Informed, utterly blindsiding account.” - Booklist, starred review It’s falling from the sky and in the air we breathe. It’s in our food, our clothes, and our homes. It’s microplastic and it’s everywhere—including our own bodies. Scientists are just beginning to discover how these tiny particles threaten health, but the studies are alarming. In A Poison Like No Other, Matt Simon reveals a whole new dimension to the plastic crisis, one even more disturbing than plastic bottles washing up on shores and grocery bags dumped in landfills. Dealing with discarded plastic is bad enough, but when it starts to break down, the real trouble begins. The very thing that makes plastic so use...
The Grand Illusion
Historical fiction inspired by the War Office response to the Nazi obsession with the occult Step forward Daphne Devine - you are about to change the course of the war ‘A breathtaking historical thriller.’ Erin Kelly, author of The Skeleton Key 'Vivid and thoroughly entertaining... More, please.' Guardian, best crime and thrillers June 1940. As World War Two rages, Daphne Devine remains in London, performing each night as assistant to stage magician Jonty Trevelyan, aka the Grand Mystique. Then the secret service call. For, aware of Hitler’s belief in the occult, the war office has set up a hidden cohort to exploit this quirk in the enemy’s chain of command. Daphne and Jonty find the...
Intellectual Property Rights
"This book analyses the impact of diverse intellectual property rights (IPR) regimes upon the development process". -- PAGE [1].
