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Connexin Methods and Protocols
Direct cell–cell communication is a common property of multicellular organisms that is achieved through membrane channels which are organized in gap junctions. The protein subunits of these intercellular channels, the connexins, form a multigene family that has been investigated in great detail in recent years. It has now become clear that, in different tissues, connexins speak several languages that control specific cellular functions. This progress has been made possible by the availability of new molecular tools and the improvement of basic techniques for the study of membrane channels, as well as by the use of genetic approaches to study protein function in vivo. More important, connex...
Encyclopedia of Cancer
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
The Politics of Pessimism in Ecclesiastes
Scholars attempt to resolve the problem of the book of Ecclesiastes’ heterodox character in one of two ways, either explaining away the book’s disturbing qualities or radicalizing and championing it as a precursor of modern existentialism. This volume offers an interpretation of Ecclesiastes that both acknowledges the unorthodox nature of Qoheleth’s words and accounts for its acceptance among the canonical books of the Hebrew Bible. It argues that, instead of being the most secular and modern of biblical books, Ecclesiastes is perhaps one of the most religious and primitive. Bringing a Weberian approach to Ecclesiastes, it represents a paradigm of the application of a social-science methodology.
Gap Junctions in Development and Disease
Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Extracellular and Intracellular Signaling
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Where's Gary?
After SpongeBob forgets to feed Gary, his pet snail, for a week, he decides to leave, forcing SpongeBob and Patrick to search all over town for him.
Sit, Ubu, Sit
A sports-crazed kid from Bensonhurst, Brooklyn, Gary David Goldberg never imagined he’d end up in Hollywood, let alone make it big there. But as a twenty-five-year-old waiter in Greenwich Village he met Diana, the love of his life; followed her out to Northern California; then moved in and never moved out. He also, without realizing it, put himself on track to found UBU Productions (named after his beloved Labrador retriever) and become a successful creator of such family sitcoms as Family Ties, Brooklyn Bridge, and Spin City.* In Sit, Ubu, Sit, award-winning writer/producer Goldberg tells the mostly upbeat, sometimes difficult, and frequently hilarious tale of his improbable career and the people who have filled it. A love story and a rare behind-the-scenes look at the entertainment industry, Sit, Ubu, Sit proves that it is possible to be creative and successful while holding on to your integrity, your family, and your sense of humor. *with Bill Lawrence
Ancient and Traditional Foods, Plants, Herbs and Spices used in Cancer
The use of different foods, herbs, and spices to treat or prevent disease has been recorded for thousands of years. Egyptian papyrus, hieroglyphics and ancient texts from the Middle East have described the cultivation and preparations of herbs and botanicals to “cure the sick.” There are even older records from China and India. Some ancient scripts describe the use of medicinal plants which have never been seen within European cultures. Indeed, all ancient civilizations have pictorial records of different foods, herbs, and spices being used for medical purposes. However, there are fundamental questions pertaining to the scientific evidence for the use of these agents or their extracts in...
