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Gap Junctions in Development and Disease
Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Tumor Marker and Carcinogenesis
Cancer may be regarded as a group of diseases characterized by an (i) abnormal growth of cells (ii) ability to invade adjacent tissue and even distant organs and(iii) the eventual death of the affected patient if the tumor has progressed beyond that stage when it can be successfully removed.
The Endometrium
The Endometrium is devoted to a comprehensive multi-disciplinary account of the uterine endometrium. This book is the first to define the regulatory biological interrelationships between epithelial and stromal cell phenotypes, endothelial cells, extracellular matrix and immunobiological elements. It highlights their relevance to clinical conditions
Lipids in Health and Disease
Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either g...
Cryptorchidism: Causes and Consequences
Cryptorchidism is the failure of one or both testes to descend into the scrotum at birth or shortly thereafter, depending on species, or the ascent of previously descended testes later in life. It is the commonest of all congenital conditions in the human representing between 1 and 9% of all male babies born. It is also common in domestic species such as pigs, dogs and horses. Importantly, cryptorchidism is seen as a sentinel of fetal well-being and is associated with other less common ailments such as testis cancer and hypospadias as part of the testicular dysgenesis syndrome (TDS), as well as being linked to maternal smoking and intrauterine growth restriction. It also likely results from ...
CCN Proteins
- First such book in the CCN field - Chapters are written by the most prominent specialists in the field
Trophoblast Invasion and Endometrial Receptivity
Interest in mechanisms of embryo implantation is increasing, particularly with the realization that failure of implantation after in vitro fertilization and embryo transfer places significant limits on the success of treatment. In addition, there is a need to provide hypotheses, and ultimately mechanisms, for the high rates of embryonic loss in women in the population at large. Traditionally, implantation research has concentrated on genetics and endocrinology without providing many therapeutic benefits. A new era is now beginning with the application of modem cellular and molecular approaches to the investigation of the relationship between trophoblast and endometrium. At the same time, old...
The Endometrium
The first edition of The Endometrium was a landmark publishing event in reproductive biology and medicine. Many important developments have occurred in the field, and this new edition has been substantially updated and expanded to include new topics with an improved format. With the addition of several new authors and topics, the Second Edition of
Connexins
Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses specific needs of the scientific community; it is a comprehensive and comprehensible narrative of the uncommonly diverse connexin field, making previously hard-to-find information easily accessible, while also presenting intelligible insights into the extensive experimental methods and conceptual frameworks necessary to appreciate and understand the important roles that connexin channel proteins play in health and disease.
