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Antisense Drug Technology
This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds. Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes! Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses novel formulations of antisense dr...
Comprehensive Natural Products Chemistry
Comprehensive Natural Products Chemistry
Geomorphology
This textbook provides a modern, quantitative and process-oriented approach to equip students with the tools to understand geomorphology. Insight into the interpretation of landscapes is developed from basic principles and simple models, and by stepping through the equations that capture the essence of the mechanics and chemistry of landscapes. Boxed worked examples and real-world applications bring the subject to life for students, allowing them to apply the theory to their own experience. The book covers cutting edge topics, including the revolutionary cosmogenic nuclide dating methods and modeling, highlights links to other Earth sciences through up-to-date summaries of current research, and illustrates the importance of geomorphology in understanding environmental changes. Setting up problems as a conservation of mass, ice, soil, or heat, this book arms students with tools to fully explore processes, understand landscapes, and to participate in this rapidly evolving field.
Rock Avalanches
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Gold and its Complexes in Anticancer Chemotherapy
This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.
Molecules at Work
This book contains the contributions of selected young chemists from the field of nanotechnology and material sciences. The contributions are grouped under the following umbrella topics: Self assembly Nanomaterials Molecular Machinery This volume is an indispensable read for all materials scientists, organic, and inorganic chemists, Ph.D. students in chemistry and material sciences interested in seeing what tomorrow's chemistry will look like.
Treatise on Geomorphology
The changing focus and approach of geomorphic research suggests that the time is opportune for a summary of the state of discipline. The number of peer-reviewed papers published in geomorphic journals has grown steadily for more than two decades and, more importantly, the diversity of authors with respect to geographic location and disciplinary background (geography, geology, ecology, civil engineering, computer science, geographic information science, and others) has expanded dramatically. As more good minds are drawn to geomorphology, and the breadth of the peer-reviewed literature grows, an effective summary of contemporary geomorphic knowledge becomes increasingly difficult. The fourteen...
Antisense Research and Applications
Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
Antisense Research and Application
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Principles and Practice of Analytical Techniques in Geosciences
This book presents a comprehensive overview of the latest developments in chemical detection science in the field of Geoscience, written for both postgraduates and professional researchers.
