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Molecular and Clinical Advances in Anticancer Drug Resistance
The importance of drug resistance in cancer chemotherapy cannot be over stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with the...
Gene Transfer and the Ethics of First-in-Human Research
Examines the ethical and policy dimensions of testing novel medical interventions in human beings for the first time.
Genes and Genomics
This latest volume addresses the contemporary issues related to recombination in filamentous fungi, EST data mining, fungal intervening sequences, gene silencing, DNA damage response in filamentous fungi, cfp genes of Neurospora, developmental gene sequences, site-specific recombination, heterologous gene expression, hybridization and microarray technology to enumerate biomass. This volume also analyse the current knowledge in the area of hydrophobins and genetic regulation of carotenoid biosynthesis. Over fifty world renowned scientist from both industry and academics provided in-depth information in the field of fungal genes and genomics.
The Cambridge Companion to Choral Music
Bringing together perspectives on history, global activity and professional development, this Companion provides a unique overview of choral music.
Pathology Reviews • 1990
Rubin and Damjanov's latest volume of Pathology Reviews highlights the latest progress in the interface of biology and disease. Forefront techniques and experimental models that were once considered exotic or esoteric, are explored here in the context of understanding more fully the processes involved in human disease. Topics include: regulation of liver growth • contractile cells in lungs • mineral formation in bone • folate metabolism • the "riddle of the mast cell" • HLA antigens • interleukin 6 • IgA nephropathy • Goodpasture syndrome • anti-basement membrane glomerulonephropathy • molecular mechanisms of oncogenesis • molecular diagnosis of cancer • inhibition of intercellular communication in carcinogenesis • DNA repair and its pathogenetic implications • human and rat mammary tumorigenesis. Pathology Reviews • 1990 is essential reading for everyone concerned with the mechanisms of disease.
Forthcoming Books
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Informational Biopolymers of Genes and Gene Expression
This new text examines thebiophysics and biochemistry of nucleic acids and proteins, carving outthe dynamic interface between chemistry and molecular biology, and providing adetailed picture of nucleic acids and proteins, their structures, biologicalproperties, and origins and evolution.
Theoria
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Molecular Imaging with Reporter Genes
Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.
