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The Turnstone is a vivid and wide-ranging account of more than sixty years of travel, medical research and clinical practice. Geoffrey Dean was born in Wales in 1918 and trained as a doctor in Liverpool before serving with distinction as a medical officer in Bomber Command. After the war he moved to South Africa, where he lived with his family for the next twenty years. During this period Dean studied the epidemiology of porphyria, a disease that can cause paralysis; his book The Porphyrias was first published in 1963. Geoffrey Dean became Director of the Medico-Social Research Board of Ireland in 1968. The author’s research has taken him around the world, and besides his research findings, the book has a rich array of anecdotes and adventures, ranging from the threat of imprisonment in South Africa to a period spent as the personal physician to the multi-millionaire Governor of the Fiji Islands.
Comprehensive text highlighting current clinical research in the area of multiple sclerosis. Includes expanded coverage of genetics, neurobiology, pathophysiology, and historical background.
Excluding the biological polymers proteins, lipids and nucleic acids, modified tetrapyrroles are the biological molecules that have had the greatest impact on the evolution of life over the past 4 billion years. They are involved in a wide variety of fundamental processes that underpin central primary metabolism in all kingdoms of life, from photosynthesis to methanogenesis. Moreover, they bring colour into the world and it is for this reason that these compounds have been appropriately dubbed the ‘pigments of life’. To understand how and why these molecules have been so universally integrated into the life processes one has to appreciate the chemical properties of the tetrapyrrole scaffold and, where appropriate, the chemical characteristics of the centrally chelated metal ion. This book addresses why these molecules are employed in Nature, how they are made and what happens to them after they have finished their usefulness.
Reprint of the original, first published in 1866.
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