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Lost Sex
Sex is the queen of problems in evolutionary biology. Generations of researchers have investigated one of the last remaining evolutionary paradoxes: why sex exists at all. Given that sexual reproduction is costly from an evolutionary point of view, one could wonder why not all animals and plants reproduce asexually. Dozens of contemporary hypotheses attempt to explain the prevalence of sex and its advantages and predict the early extinction of fully asexual lineages. The major theme of this book is: what is the fate of animal and plant groups in which sex is lost? Initial chapters discuss theory behind asexual life: what major disadvantages do asexual groups have to face, what are the geneti...
Cross-Cultural Psychology
Dynamic author team provides comprehensive overview with focus on critical-thinking. The fifth edition continues a heavy focus on applying critical thinking framework in examining, analyzing, and evaluating psychological data. With significant rewriting and additional new topics as well as updated references on new research, Cross-Cultural Psychology keeps pace with the rapidly changing conditions of modern times. The dynamic team from two different worlds bring a unique set of experiences and perceptions in writing this book. Eric Shiraev was raised in the city of Leningrad in the former Soviet Union and David Levy is from Southern California,. Between the diverse backgrounds and having eac...
Targeted Delivery of Small and Macromolecular Drugs
Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou
Leucocyte Trafficking
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.
