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The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.
This book aims to stimulate new thinking on the roles of river contracts in the protection and management of hydrographic resources and ecosystems and in the sustainable development of dependent territories and communities. Up-to-date information is provided on a range of topics relating to river contracts, including their relevance to implementation of the EU Water Framework Directive on integrated river basin management. The importance of river contracts for innovation in territorial planning and governance is explored with the aid of comparative analysis between France and Italy that encompasses water management policies, legislative frameworks, contents and procedures, and stakeholder rules and participation. This analysis is supported by enlightening case studies in urbanized and rural contexts within the two countries. The book will be of high interest for all who wish to understand the potential of river contracts to create innovative forums for dialogue and knowledge sharing between public/private stakeholders and local communities and to prompt a new form of governance of river ecosystems and territories that is compliant with the subsidiarity principle.
This book collects a series of contributions addressing the various contexts in which the theory of Lie groups is applied. A preliminary chapter serves the reader both as a basic reference source and as an ongoing thread that runs through the subsequent chapters. From representation theory and Gerstenhaber algebras to control theory, from differential equations to Finsler geometry and Lepage manifolds, the book introduces young researchers in Mathematics to a wealth of different topics, encouraging a multidisciplinary approach to research. As such, it is suitable for students in doctoral courses, and will also benefit researchers who want to expand their field of interest.
This book examines the phenomenon of urban fear – the increasing anxiety over crime and violence in Western cities despite their high safety – with a view to developing a comprehensive, critical, exploratory theory of fear, space, and urban planning that unravels the paradoxes of their mutual relations. By focusing especially on the southern European cities of Palermo and Lisbon, the book also aims to expand upon recent studies on urban geopolitics, enriching them from the perspective of ordinary, as opposed to global, cities. Readers will find enlightening analysis of the ways in which urban fear is (re)produced, including by misinformative discourses on security and fear and the politi...
The work represents a significant scientific advancement on text linguistics from three different viewpoints. The first chapter provides an overview of the history of text linguistics from a broader perspective than usual, offering a complete reference framework. The second chapter presents the procedural approach to the study of text linguistics in a concise way, including a critical comparison with other perspectives. The third chapter constructs a very unusual bridge between theoretical linguistics and classical studies in that it takes a literary text in Latin from the early imperial period as its case study. This combination is rare, as theoretical linguists are usually oriented to modern languages and classicists are not generally inclined to the study of formal linguistics. It also offers an interesting perspective that intersects the studies of general linguistics and glottology, which makes this volume of interest to general linguists, classicists, philologists and literary critics alike.
"How can people involved in carceral interventions learn from work in carceral settings outside the United States? This volume addresses this question by gathering international perspectives to the field of education in prison that could inform carceral interventions elsewhere, including in the United States"--
This book proposes a philosophy of care in a global age. It discusses the distinguishing and opposing pathologies produced by globalization: unlimited individualism or self-obsession, manifested as (Promethean) omnipotence and (narcissistic) indifference, and endogamous communitarianism or an ‘us’-obsession that results in conflict and violence. The polarization between a lack and an excess of pathos is reflected in the distorted forms taken on by fear. The book advocates a metamorphosis of fear, which may restore in the subject an awareness of vulnerability and become the precondition for moral action. Such awareness and the recognition of the condition of contamination caused by the other’s unavoidable presence teach us to fear for rather than be afraid of. Fear for the world means care of the world, and care, understood as concern and solicitude, is a new notion of responsibility, in which the stress is shifted to a relational subject capable of responding to and taking care of the other. From a global perspective, the proposed vision of care also compels us to explore a new paradigm of justice.
Problem Gambling in Europe Challenges, Prevention, and Interventions Edited by Gerhard Meyer, University of Bremen, Germany Tobias Hayer, University of Bremen, Germany Mark Griffiths, Nottingham Trent University, United Kingdom As a leisure activity, gambling dates back to ancient times. More recently, the surge in avenues for gambling—casinos, sports betting, lotteries, and remote media (e.g.,Internet, mobile phone, interactive television) among them—finds growing numbers of people losing control over their gambling behaviour, usually at great personal and financial expense. Problem Gambling in Europe is the first book to offer a robust international knowledge base compiled by an interd...
This book offers as comprehensive an overview as possible of the lithostratigraphy of the Italian region of Sicily, taking into account the multiplicity of formational and terminological variability developed over more than a century of studies and publications. It presents stratigraphic terminology, the geological lexicon and the main stratigraphic subdivisions that are not familiar to Sicilian geologists. The new stratigraphic methods and the use of formations as mapping units have prompted the acquisition of new lithostratigraphic data, and a review of the previous units and their comparison with the new collected data, enabling the definition of a number of new lithostratigraphic units. The book summarizes the results in 77 worksheets containing the most important information regarding the lithological, sedimentological and microfacies characteristics, the measured thicknesses, areal extent and the regional aspects, the paleoenvironmental, paleogeographic and paleo-tectonics setting, compiled according to standard procedures and nomenclature rules provided by the International Commission on Stratigraphy (ICS).