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Despite the long association of organohalogen compounds with human activities, nature is the producer of nearly 5,000 halogen-containing chemicals. Once dismissed as accidents of nature or isolation artifacts, organohalogen compounds represent an important and ever growing class of natural products, in many cases exhibiting exceptional biological activity. Since the last comprehensive review in 1996 (Vol. 68, this series), there have been discovered an additional 2,500 organochlorine, organobromine, and other organohalogen compounds. These natural organohalogens are biosynthesized by bacteria, fungi, lichen, plants, marine organisms of all types, insects, and higher animals including humans. These compounds are also formed abiogenically, as in volcanoes, forest fires, and other geothermal events.In some instances, natural organohalogens are precisely the same chemicals that man synthesizes for industrial use, and some of the quantities of these natural chemicals far exceed the quantities emitted by man.
This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way.* A critical review of the heterocyclic literature published during 2007 * Presents specialized reviews * Chapters all written by leading researchers in their field
Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. ...
This is the 19th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2006. As with previous volumes in the series, Volume 19 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way. A critical review of the heterocyclic literature published during 2006 Presents specialized reviewsChapters all written by leading researchers in their field
The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organis...
It's the world's most successful public health insecticide, saving millions upon millions of lives from preventable, insect-borne diseases. Yet despite decades of use and thousands of studies on its effects, DDT remains the world's most misunderstood chemical. Orchestrated, well-financed, earnest, but myth-based campaigns forced most countries to ban DDT without scientific justification. These campaigns created a climate of irrational fear and ignorant prejudice around DDT and have condemned millions of the world's most vulnerable people to death. The Excellent Powder dispels these myths and sets the record straight. It reviews the fascinating history of this chemical that changed the worl...
Whether or not you've heard of PCBs (polychlorinated biphenyls), it's likely that this toxic chemical can be found in your cells. PCBs were invented in 1920 for the electronics industry, fueled the WWII military machine, then were put to domestic uses, and finally came to be present in every corner of the earth. Because PCBs were outlawed in 1976, most people think they are no longer a threat. However, like many industrial chemicals, PCBs persist in our environment and continue to accumulate in practically every life form on earth, becoming more concentrated in the tissues of those highest on the food chain--like us. In Biocidal, investigative journalist Ted Dracos explores the science behin...
What’s it really like to be a chemist? Leading chemists share what they do, how they do it, and why they love it. “Letters to a young ...” has been a much-loved way for professionals in a field to convey their enthusiasm and the realities of what they do to the next generation. Now, Letters to a Young Chemist does the same for the chemical sciences. Written with a humorous touch by some of today’s leading chemists, this book presents missives to “Angela,” a fictional undergraduate considering a career in chemistry. The different chapters offer a mix of fundamental principles, contemporary issues, and challenges for the future. Marye Anne Fox, Chancellor of the University of Calif...
Comprehensive Organic Functional Group Transformations II (COFGT-II) will provide the first point of entry to the literature for all scientists interested in chemical transformations. Presenting the vast subject of organic synthesis in terms of the introduction and interconversion of all known functional groups, COFGT-II provides a unique information source documenting all methods of efficiently performing a particular transformation. Organised by the functional group formed, COFGT-II consists of 144 specialist reviews, written by leading scientists who evaluate and summarise the methods available for each functional group transformation. Also available online via ScienceDirect – featuring...
Located in the southwestern part of San Francisco, the Sunset District developed late because of its distance from downtown and because of the sand dunes that covered it for thousands of years. After 1900, as public transportation spread and the automobile became available, housing and streets soon began to cover the Sunset District dunes.