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How Tobacco Smoke Causes Disease
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Algebraic Homotopy
This book gives a general outlook on homotopy theory; fundamental concepts, such as homotopy groups and spectral sequences, are developed from a few axioms and are thus available in a broad variety of contexts. Many examples and applications in topology and algebra are discussed, including an introduction to rational homotopy theory in terms of both differential Lie algebras and De Rham algebras. The author describes powerful tools for homotopy classification problems, particularly for the classification of homotopy types and for the computation of the group homotopy equivalences. Applications and examples of such computations are given, including when the fundamental group is non-trivial. Moreover, the deep connection between the homotopy classification problems and the cohomology theory of small categories is demonstrated. The prerequisites of the book are few: elementary topology and algebra. Consequently, this account will be valuable for non-specialists and experts alike. It is an important supplement to the standard presentations of algebraic topology, homotopy theory, category theory and homological algebra.
Shadowing the Anthropocene: Eco-Realism for Turbulent Times
A spectre is haunting humanity: the spectre of a reality that will outwit and, in the end, bury us. "The Anthropocene," or The Human Era, is an attempt to name our geological fate - that we will one day disappear into the layer-cake of Earth's geology - while highlighting humanity in the starring role of today's Earthly drama. In Shadowing the Anthropocene, Adrian Ivakhiv proposes an ecological realism that takes as its starting point humanity's eventual demise. The only question for a realist today, he suggests, is what to do now and what quality of compost to leave behind with our burial. The book engages with the challenges of the Anthropocene and with a series of philosophical efforts to...
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One of the founders of the posthumanities, Donna J. Haraway is professor in the History of Consciousness program at the University of California, Santa Cruz. Author of many books and widely read essays, including the now-classic essay "The Cyborg Manifesto," she received the J.D. Bernal Prize in 2000, a lifetime achievement award from the Society for Social Studies in Science. Thyrza Nicholas Goodeve is a professor of Art History at the School of Visual Arts.
Functional Somatic Symptoms in Children and Adolescents
This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.
Self-Build Homes
Self-Build Homes connects the burgeoning interdisciplinary research on self-build with commentary from leading international figures in the self-build and wider housing sector. Through their focus on community, dwelling, home and identity, the chapters explore the various meanings of self-build housing, encouraging new directions for discussions about self-building and calling for the recognition of the social dimensions of this process, from consideration of the structures, policies and practices that shape it, through to the lived experience of individuals and households.Divided into four parts – Discourse, Rationale, Meaning; Values, Lifestyles, Imaginaries; Community and Identity; and ...
Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy
Oral contraceptives for family planning worldwide have revolutionized the reproductive lives of millions of women since their introduction in the 1960s. Later on, a variety of side-effects including cardiovascular diseases was recognized. In response to these concerns, new generations of combined oral contraceptives were developed that featured lower dose of estrogen and newer, more potent progestogens. The effectiveness and ease of use of combined hormonal contraceptives suggest that they will continue to be used to a significant extent in the future. This ninety-first volume of IARC Monograp.
The Perfect Slime
The Perfect Slime presents the latest state of knowledge and all aspects of the Extracellular Polymeric Substances, (EPS) matrix – from the ecological and health to the antifouling perspectives. The book brings together all the current material in order to expand our understanding of the functions, properties and characteristics of the matrix as well as the possibilities to strengthen or weaken it. The EPS matrix represents the immediate environment in which biofilm organisms live. From their point of view, this matrix has paramount advantages. It allows them to stay together for extended periods and form synergistic microconsortia, it retains extracellular enzymes and turns the matrix int...
