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The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery of additional genes associated with human cardiac diseases, the analysis of large dataset of genetic information uncovered a much more complex and variegated landscape, which often departs from the comfort zone of the monogenic Mendelian diseases image that clinical molecular geneticists have been well acquainted with for many decades. It is now clear that, in addition to highly penetrant genetic variants, which in isolation are able to recapitulate the full clinical presen...
Now in an extensively revised third edition with 65% new material, this is the authoritative reference on posttraumatic stress disorder (PTSD). Contributors examine the breadth of current knowledge on the mechanisms by which stressful events can alter psychological processes, brain function, and individual behavior. Risk and protective factors across development and in specific populations are explored. Reviewing the state of the science of assessment and treatment, the volume covers early intervention and evidence-based individual, couple/family, and group therapies. Conceptual and diagnostic issues are addressed and key questions for the next generation of researchers are identified. New t...
An essential collection that advances our understanding of how cities influence our health More than half the world's population lives in cities -- a figure that will grow to two-thirds by 2030. As global populations rapidly consolidate around urban centers, the scientific understanding of what this means for human health faces a new and greater urgency. Urban Health connects urban exposures -- the experiences, choices, and behaviors shaped by living in a city -- to their impact on population health. By using the ubiquitous aspects of the urban experience as a lens to study these exposures across borders and demographics, it offers a new, scalable framework for understanding health and disease. Its applications to public health, epidemiology, and social science are virtually unlimited. Enriched with case studies that consider the state of health in cities all over the world, this book does more than capture the state of a nascent field; it holds a critical mirror to itself, considering the next decade and arming a new generation with the tools for research and practice.
Widely regarded as the definitive reference, this handbook brings together foremost authorities on posttraumatic stress disorder (PTSD). Diagnostic, conceptual, and treatment issues are reviewed in depth. The volume examines the causes and mechanisms of PTSD on multiple levels, from psychological processes to genes and neurobiology. Risk and resilience processes are addressed across development and in specific populations. Contributors describe evidence-based assessment and treatment approaches as well as promising emerging interventions. The integrative concluding chapter identifies key unanswered questions with important implications for science and practice. New to This Edition *Reflects major research advances and the new diagnostic criteria in DSM-5. *Chapters on the dissociative subtype of PTSD, child assessment, couple and family therapies, and group treatments. *Chapters on research methods, Internet-based interventions, telemental health, and implementation of best practices. *Many new authors and extensively revised chapters.
Trauma, stress, and disasters are impacting our world. The scientific advances presented address the burden of disease of trauma- and stressor-related disorders. This book is about their genetic, neurochemical, developmental, and psychological foundations, epidemiology, and prevention, screening, diagnosis, and treatment. It presents evidence-based psychotherapeutic, psychopharmacological, public health, and policy interventions.
An edited volume describing the latest developments in approaching the problem of polymer sequence analysis, with special emphasis on the most relevant biopolymers (peptides and DNA) but not limited to them. The chapters will include peptide sequence analysis, DNA sequence analysis, analysis of biopolymers and nonpolymers, sequence alignment problems, and more.
As a practicing child psychiatrist and mother of three, Jodi Gold has a unique understanding of both the mind-boggling benefits and the serious downsides of technology. Dr. Gold weaves together scientific knowledge and everyday practical advice to help you foster your child's healthy relationship to technology, from birth to the teen years. You'll learn: *How much screen time is too much at different ages. *What your kids and teens are actually doing in all those hours online. *How technology affects social, emotional, and cognitive development. *Which apps and games build smarts and let creativity shine. *How your own media habits influence your children. *What you need to know about privacy concerns, cyberbullying, and other dangers. *Ways to set limits that the whole family can live with. Winner (Second Place)—American Journal of Nursing Book of the Year Award, Child Health Category
This volume brings together the leaders in the field of PTSD research to present an up-to-date summary and understanding of this complex disorder. All of our current knowledge and controversies concerning the diagnosis, epidemiology, course, pathophysiology and treatment are described in detail. The evidence for efficacy for each of the different forms of psychotherapy and pharmacotherapy is reviewed. Particular attention is paid to at-risk groups, including minorities, and coverage of PTSD throughout the world is reviewed as well. The authors present state-of-the-art findings in genetics, epigenetics, neurotransmitter function and brain imaging to provide the most current and comprehensive review of this burgeoning field.
Trauma, stress, and manmade and natural disasters are increasingly impacting individuals and communities. The clinical and scientific advances presented here strive to address the rapidly expanding individual and community burden of disease resulting from the experience of traumatic or stressful events. The authors describe the suffering which trauma- and stressor-related disorders (TSRDs) cause, and explain in 30 concise chapters the state of the science for the DSM-5 trauma- and stressor-related disorders with regard to pathogenesis, diagnostic assessment and approach to treatment. This volume presents the genetic, neurochemical, developmental, and psychological foundations and epidemiolog...
“Compelling, essential reading for understanding the underpinnings of psychopathy.” — M. E. Thomas, author of Confessions of a Sociopath For his first fifty-eight years, James Fallon was by all appearances a normal guy. A successful neuroscientist and professor, he’d been raised in a loving family, married his high school sweetheart, and had three kids and lots of friends. Then he learned a shocking truth that would not only disrupt his personal and professional life, but would lead him to question the very nature of his own identity. While researching serial killers, he uncovered a pattern in their brain scans that helped explain their cold and violent behavior. Astonishingly, his own scan matched that pattern. And a few months later he learned that he was descended from a long line of murderers. Fallon set out to reconcile the truth about his own brain with everything he knew as a scientist about the mind, behavior, and personality.