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Advanced Time-Correlated Single Photon Counting Techniques
In 1984 Desmond O’Connor and David Phillips published their comprehensive book „Time-correlated Single Photon Counting“. At that time time-correlated s- gle photon counting, or TCSPC, was used primarily to record fluorescence decay functions of dye solutions in cuvettes. From the beginning, TCSPC was an am- ingly sensitive and accurate technique with excellent time-resolution. However, acquisition times were relatively slow due to the low repetition rate of the light sources and the limited speed of the electronics of the 70s and early 80s. Moreover, TCSPC was intrinsically one-dimensional, i.e. limited to the recording of the wa- form of a periodic light signal. Even with these limitations, it was a wonderful te- nique. More than 20 years have elapsed, and electronics and laser techniques have made impressive progress. The number of transistors on a single chip has approximately doubled every 18 months, resulting in a more than 1,000-fold increase in compl- ity and speed. The repetition rate and power of pulsed light sources have increased by about the same factor.
Iran Between Two Revolutions
Emphasizing the interaction between political organizations and social forces, Ervand Abrahamian discusses Iranian society and politics during the period between the Constitutional Revolution of 1905-1909 and the Islamic Revolution of 1977-1979. Presented here is a study of the emergence of horizontal divisions, or socio-economic classes, in a country with strong vertical divisions based on ethnicity, religious ideology, and regional particularism. Professor Abrahamian focuses on the class and ethnic roots of the major radical movements in the modem era, particularly the constitutional movement of the 1900s, the communist Tudeh party of the 1940s, the nationalist struggle of the early 1950s,...
Auditory Prostheses
Cochlear implants are currently the standard treatment for profound sensorineural hearing loss. In the last decade, advances in auditory science and technology have not only greatly expanded the utility of electric stimulation to other parts of the auditory nervous system in addition to the cochlea, but have also demonstrated drastic changes in the brain in responses to electric stimulation, including changes in language development and music perception. Volume 20 of SHAR focused on basic science and technology underlying the cochlear implant. However, due to the newness of the ideas and technology, the volume did not cover any emerging applications such as bilateral cochlear implants, combi...
Time-correlated single photon counting
Time-correlated Single Photon Counting has been written in the hope that by relating the authors' experiences with a variety of different single photon counting systems, they may provide a useful service to users and potential users of this formidably sensitive technique. Of all the techniques available to obtain information on the rates of depopulation of excited electronic singlet states of molecular species, monitoring of fluorescence provides, in principle, the simplest and most direct measure of concentration. This volume comprises eight chapters, with the first focusing on the time dependence and applications of fluorescence. Succeeding chapters go on to discuss basic principles of the single photon counting lifetime measurement; light sources; photomultipliers; electronics; data analysis; nanosecond time-resolved emission spectroscopy; time dependence of fluorescence anisotropy. This book will be of interest to practitioners in the field of chemistry.
Cyclin Dependent Kinase 5 (Cdk5)
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Aptamers for Medical Applications
This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.
Adenovirus Methods and Protocols
Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. The protocols presented are written by trendsetting researchers.
The Armenians in the Medieval Islamic World
In this first of a massive three-volume work, Seta B. Dadoyan studies the Armenian experience in the medieval Islamic world and takes the reader through hitherto undiscovered paradigmatic cases of interaction with other populations in the region. Being an Armenian, Dadoyan argues, means having an ethnic ancestry laden with narratives drawn from the vast historic Armenian habitat. Contradictory trends went into the making of Armenian history, yet most narratives fail to reflect this rich texture. Linking Armenian-Islamic history is one way of dealing with the problem. Dadoyan’s concern is also to outline revolutionary elements in the making of Armenian ideologies and politics. This extensiv...
A Dictionary of Weights and Measures for the British Isles
The complexity of medieval & modern pre-metric weights & measures (W&M) in Britain presents an obstacle to scholarly research on Western European econ. history. The problem is: the approx. dimensions of many non-standardized measuring units, used by both the Crown & the regional & local markets, varied from time to time & from place to place; & the dimensions even of standard W&M used in any period are poorly understood. This book will clarify the confusion & bring a new focus to the field of metrology & a new understanding of the units. It includes: tables for rapid identification of all ruling English, Scottish, Irish, or Welsh sovereigns; current English Imperial, Amer. Customary, & metric units; & the basic equiv. for these W&M; & A Dict. of Brit. W&M.
