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Oral Bioavailability and Drug Delivery
ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability...
Drug Delivery
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Carbon Monoxide in Drug Discovery
CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest physiological and therapeutic studies of carbon monoxide In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. Organi...
Unlimited Online Game
Long Fei was a jobless youth who had coincidentally entered a game from the future. Long Fei raised his sword and roared towards the sky: "Good, I will not only rewrite history, but also live a wonderful life. "Let me tell you, I'm not playing the game, I'm playing the game!"
Records of Qin Dynasty
Zi Zhi Tong Jian (Chinese: 资治通鉴;English: "Comprehensive Mirror in Aid of Governance") is a pioneering reference work in Chinese historiography, published in 1084 in the form of a chronicle. In 1065 AD, Emperor Yingzong of Songordered the great historian Sima Guang (1019–1086 AD) to lead with other scholars such as his chief assistants Liu Shu, Liu Ban and Fan Zuyu,[1] the compilation of a universal history of China. The task took 19 years to be completed,and, in 1084 AD, it was presented to his successor Emperor Shenzong of Song. The Zizhi Tongjian records Chinese history from 403 BC to 959 AD, covering 16 dynasties and spanning across almost 1,400 years,and contains 294 volumes (å...
The Concert
A group of Albanian friends are torn apart by the political turmoil of the mid 1970s, as the nation's diplomatic ties with China begin to unravel, and their personal entanglements follow suit in the face of governmental insecurity.
Toward a Democratic China
During the 1980s, as director of the Political Science Institute at the Chinese Academy of Social Science - China's most prestigious think-tank - Yan Jiaqi proposed many of the political reforms undertaken by the Chinese government, including term limitations for high-level officials, separation of party and state, and creation of a civil service system. In this book, Yan summarizes the thinking behind these and other reforms yet to be adopted on China's difficult path to democracy. Originally published in 1989, Yan's account of his early training in science, the Cultural Revolution, the Tiananmen Incident of 1976, and the Democracy Wall Movement of 1978-79 gives a frank appraisal of the for...
Hydrogen Sulfide
HYDROGEN SULFIDE Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation req...
Evaluation of Drug Candidates for Preclinical Development
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in...
Nucleic Acids in Medicinal Chemistry and Chemical Biology
Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nu...
