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Neuro-Immune Interactions in Inflammation and Autoimmunity
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural c...
Gut Feelings: The Patient's Story
Gut Feelings: The Patient’s Story takes our knowledge about highly prevalent conditions such as IBS and other Disorders of Gut Brain Interaction further by learning from the patient's illness journey. This book offers a deeper dive into the experience of the illness through the patient’s perspective, giving their stories of illness and their experiences with the health care system. Additionally, we learn the key messages that helped them recover or learn to adapt to their illness. Through the use of patient narratives, we find quick connection for patients to identify with common experiences and take these lessons forward to their own medical care. These narratives are also a helpful tool for providers to learn the real world of patient illness experience and their role in improving clinical outcomes.
Tissue-Resident Macrophages
This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.
Gut Feelings- Disorders of Gut Brain Interactions and the Patient-Doctor Relationship
This book is written for patients and their doctors by an internationally acclaimed gastroenterologist and patient advocate. It contains up-to-date knowledge on the science, diagnosis, and treatment of all the Disorders of Gut-Brain Interaction (formerly called Functional GI Disorders) and offers techniques to maximize the patient-doctor relationship. For the patient, it will help you to: • Understand and manage your GI symptoms and improve the care you receive • Talk with your doctors—learn what to say, what to ask, and what to do when the visit is not going well • Find the best clinical programs for treating DGBI • Understand why you have symptoms when all tests are negative For the doctor, it will help you to: • Learn the pathophysiology, diagnosis, and treatment of all Disorders of Gut-Brain Interaction (DGBI) • Elicit accurate information from the medical interview to make a precise diagnosis • Acquire communication skills to better connect with your patients
Gastrointestinal Pharmacology
This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.
Gut Feelings: Disorders of Gut-Brain Interaction and the Patient-Doctor Relationship
This book is written for patients and their doctors by an internationally acclaimed gastroenterologist and patient advocate. It contains up-to-date knowledge on the science, diagnosis, and treatment of all the Disorders of Gut-Brain Interaction (formerly called Functional GI Disorders) and offers techniques to maximize the patient- doctor relationship.
GABAb Receptor Pharmacology: A Tribute to Norman Bowery
This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse. The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular. - Articles written by leading investigators in the field - Informs and updates on all the latest developments
Cardiovascular Pharmacology: Heart and circulation
Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. - Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
Autonomic Nervous System
Autonomic Nervous System provides an introduction to the latest science and detailed chapters on advances in the clinical diagnosis and treatment of autonomic system disorders. The autonomic nervous system controls all involuntary actions within the human nervous system. Core body functions regulated by the autonomic system include breathing, heartbeat, blood pressure, body temperature, perspiration, and bowel, bladder and sexual function. Our understanding of the neurotransmitters associated with the autonomic nervous system has expanded over the past 15 years associated with current research efforts and are now impacting the diagnosis and treatment of autonomic nervous system disorders by ...
