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Advances in Natural Product Chemistry
First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.
The Alkaloids
The Alkaloids: Chemistry and Physiology, Volume VIII: The Indole Alkaloids focuses on the advances in the chemistry of indole alkaloids. This book discusses the tryptamine and its derivatives, postulated biosyntheses of the physostigmine ring system, and source of the alkaloids. The simple lysergic acid amides, mass spectra of mitraphylline and rhynchophylline, and alkaloids of gelsemium species are also elaborated. This text likewise covers the determination of the structure of the alkaloids, stereochemistry of cinchonamine, dimeric alkaloids of calabash curare, and chemistry of the reserpine group. Other topics include the biology of ergot and short history of its active principles up to the discovery of ergotamine. This volume is recommended for chemists and researchers interested in indole alkaloids.
The Alkaloids: Chemistry and Physiology V8
The Alkaloids: Chemistry and Physiology V8
Microbial Siderophores
In response to low iron availability in the environment most microorganisms synthesize iron chelators, called siderophores. Bacteria and fungi produce a broad range of structurally diverse siderophores, all of which show a very high affinity for ferric ions. This book presents an up-to-date overview of the chemistry, biology and biotechnology of these iron chelators. Coverage ranges from an introductory chapter to siderotyping to applications in human and plant health.
The Bile Acids Chemistry, Physiology, and Metabolism
The bile acids as principal end products of cholesterol metabolism occupy a focal position in our understanding of the role of steroids in bio logical systems. The biogenesis of bile acids from cholesterol in higher ani mals, and their functions in regulating sterol metabolism and in gastrointestinal physiology have been elucidated by the development of elegant methodo logical approaches during the last two decades. The molecular pleomorphism exhibited by the bile acids and bile alcohols in the animal kingdom is a classic example of their role in biochemical evolution. The total story of the bile acids, their chemistry, their role in normal and abnormal physiological processes, and their sig...
Organophosphorus Chemistry
Organophosphorus Chemistry provides a comprehensive annual review of the literature. Coverage includes phosphines and their chalcogenides, phosphonium salts, low coordination number phosphorus compounds, penta- and hexa-coordinated compounds, tervalent phosphorus acids, nucleotides and nucleic acids, ylides and related compounds, and phosphazenes. The series will be of value to research workers in universities, government and industrial research organisations, whose work involves the use of organophosphorus compounds. It provides a concise but comprehensive survey of a vast field of study with a wide variety of applications, enabling the reader to rapidly keep abreast of the latest developme...
Piperidine
Piperidine, one of the simplest heterocyclic systems, is found in nature as part of several alkaloid compounds. Both natural and especially unnatural piperidine derivatives present interesting pharmacological properties. From a structural viewpoint, the conformation of piperidine has been the subject of one of the fiercest controversies in structural organic chemistry in the last few years. As a result of the combined use of several spectroscopic techniques, the conformational behavior of most types of piperidine-related compounds has been clarified. Some piperidine derivatives, namely, N-acylpiperidine, &agr;-cyanopiperidines and piperidones are extremely useful and versatile intermediates ...
Terpenoids and Steroids, V.7
This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 90 years The Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However,...
Doxorubicin
Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.
Mass Spectrometry
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