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Black holes exist in galactic nuclei and in some X-ray binaries found in our own galaxy and the large Magellanic Cloud. This volume focuses on astrophysical high-energy emission processes around black holes, and the development of theoretical frameworks for interesting observational results. Contents: Black Hole Observations; Accretion Disk/Formation of Jets; Energy Extraction from Rotating Black Holes; Supernova and Gamma Ray Bursts; Black Hole Astrophysics. Readership: Graduate students, post-docs and academics in astrophysics, astronomy, cosmology and high energy physics.
Fluorescent chemosensors have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences. The interdisciplinary nature of chemosensor research has continued to grow over the last 25 years to meet the increasing needs of monitoring our environment and health. More recently, a large range of fluorescent chemosensors have been established for the detection of biologically and/or environmentally important species, and are increasingly being used to solve biological problems. The use of these molecules as imaging probes to diagnose and treat disease is gaining momentum with clear future applications. This book will bring together world-leading experts to describe the current state of play in the field and introduce the cutting-edge research and possible future directions into fluorescent chemosensors design. Chapters focus on the basic principles involved in the design of chemosensors for specific analytes, problems, and challenges in the field. Concentrating on advanced techniques and methods, the book will be of use for academics and researchers across a number of disciplines, with international appeal.
This well-illustrated book covers the full range of lung and pleural diseases from the pathologic standpoint. It has been updated from the first edition by including the most recent molecular data for the different lung diseases, tumor as well as non-tumor ones. New diagnostic tests are included, new aspects for the understanding of diseases have been added. Both diseases of adults and pediatric lung diseases are presented. The chapter on lung development has been expanded due to the many new findings being reported since the first edition. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years’ experience in the field.
First published in 1996. Always there are hills in the distance, backed by mountains, wreathed in mist, and always the sound of water. These are the things that have inspired the Korea’s poets and artists and haunt the dreams of its exiles. An eastern backbone of sharp mountains has ribs that run westward and from these wooded hills flow the water that trickles through the rice fields. Climatic maps show it to be at the centre of a small area that is almost unique in its combination of cold dry winters and hot rainy summers. Most of its plants and animals are common to the temperate zone of the Northern Hemisphere but they are tested almost to destruction by seasonal alternations of Siberian cold and summer monsoons. In May the brown desert of winter begins to shimmer in a delicate veil of green which grows into a summer jungle and dies with glory in a long warm autumn of red and gold. About 600 miles in length and 150-200 miles wide, it reaches out from the mainland like an oriental Italy, with China embracing it to the north and west and Japan only 100 miles away to the south and east. This book illuminates the reader about the history of Korea.
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to...
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
This handbook gathers together the state of the art on mathematical models and algorithms for imaging and vision. Its emphasis lies on rigorous mathematical methods, which represent the optimal solutions to a class of imaging and vision problems, and on effective algorithms, which are necessary for the methods to be translated to practical use in various applications. Viewing discrete images as data sampled from functional surfaces enables the use of advanced tools from calculus, functions and calculus of variations, and nonlinear optimization, and provides the basis of high-resolution imaging through geometry and variational models. Besides, optimization naturally connects traditional model...
Natural Product Chemistry continues to expand to exciting new frontiers of great importance in medicine. Written by international authorities in various fields of natural product chemistry, this latest volume in the well-established series Studies in Natural Products Chemistry contains 23 chapters, covering topics ranging from immunosuppressant and antimalarial compounds to bioactive substances useful in cancer and neural diseases. This present volume, will again be of great interest to research scientists and scholars working in the exciting field of new drug discovery.* Written by international authorities in the various fields of natural product chemistry* Contains 23 comprehensive articles covering topics ranging from immunosuppressant and antimalarial compounds to bioactive substances useful in cancer and neural diseases* Valuable source of information for research scientists and scholars in the field of new drug discovery
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.