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Carbohydrate-based Drug Discovery, 2 Volume Set
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
Neuroglycobiology
Carbohydrates play a major role in brain function. In the past decade, tremendous progress has been made in understanding their structure and function within the nervous system. This book presents a state of the art account of this rapidly expanding field.
Handbook of Glycosyltransferases and Related Genes
The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the ...
Comprehensive Natural Products Chemistry: Carbohydrates and their derivatives including tannins, cellulose, and related lignins
Hardbound. This volume, containing 20 chapters, focuses on the biosynthesis of the different classes of carbohydrates and their derivatives. The first part of this volume concentrates on the three classes of glycan-bearing molecules that mediate bio-recognition events, namely, glycoproteins, glycolipids, and glycosaminoglycans. Thus, the first four chapters highlight the key role played by glycosidases and glycosyl transferases in the processing of glycan chains in glycoproteins and on inhibitors of the glycosidases. The next two chapters feature the biosynthesis of glycosphingolipids, sphingolipid transport and degradation, and the regulation of glycolipid biosynthesis in developing tissues and tumor cells. Chapter 7 is devoted to the biosynthesis of proteoglycans with particular emphasis on the glycosaminoglycans. In the second part, the volume treats the molecules of importance in protozoans and bacteria. Thus, chapter 8 describes the biosynthesis o
Psychotherapy Research
This book provides readers with essential information on the foundations of psychotherapy research, and on its applications to the study of both psychotherapy process and outcome. The aim is to stimulate a reflection on these issues in a way that will benefit researchers and clinicians, as well as undergraduate and graduate students, at different levels and from different perspectives. Accordingly, the book presents a balanced mix of chapters summarizing the state of the art in the field from different viewpoints and covering innovative topics and perspectives, reflecting some of the most established traditions and, at the same time, emerging approaches in the field in several countries. The...
Psychodynamic Psychotherapy Research
Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence continues the important work of the first book published in 2009 by Humana Press (Handbook of Evidence-Based Psychodynamic Psychotherapy: Bridging the Gap Between Science and Practice). This landmark title presents in one volume significant developments in research, including neuroscience research, in psychodynamic psychotherapy by a team of renowned clinician-researchers. The demand for ongoing research initiatives in psychodynamic psychotherapy from both internal and external sources has increased markedly in recent years, and this volume continues to demonstrate the efficacy and effectiveness of a ps...
Carbohydrate Chemistry
Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccha...
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Synthetic Glycomes
Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, en...
