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One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad ...
Beginning in the late Southern Sung one sect of Confucianism gradually came to dominate literati culture and, by the Ming dynasty, was canonized as state orthodoxy. This book is a historical and textual critique of the construction of an ideologically exclusionary conception of the Confucian tradition, and how claims to possession of the truth—the Tao—came to serve power.
A collection of anecdotes, conversations, and remarks concerning historic personalities of 150 to 420 A.D. China.