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Genomics
Over the past 50 years, scientists have made incredible progress in the application of genetic research to human health care and disease treatment. Innovative tools and techniques, including gene therapy and CRISPR-Cas9 editing, can treat inherited disorders that were previously untreatable, or prevent them from happening in the first place. You can take a DNA test to learn where your ancestors are from. Police officers can use genetic evidence to identify criminals—or innocents. And some doctors are using new medical techniques for unprecedented procedures. Genomics: A Revolution in Health and Disease Discovery delves into the history, science, and ethics behind recent breakthroughs in genetic research. Authors Whitney Stewart and Hans Andersson, MD, present fascinating case studies that show how real people have benefitted from genetic research. Though the genome remains full of mysteries, researchers and doctors are working hard to uncover its secrets and find the best ways to treat patients and cure diseases. The discoveries to come will inform how we target disease treatment, how we understand our health, and how we define our very identities.
Small Molecule Therapy for Genetic Disease
Thoene summarises the substantial work that has been accomplished in the treatment of inborn errors of metabolism with simple molecules. This handbook will enable interested clinician scientists to rapidly survey the field, thus ascertaining what has been done as well as future directions for therapeutic research. Its important introductory chapters discuss the infrastructure of the field. The book closely analyses the cofactors used to augment the function of defective enzymes and the compounds that are able to utilise an alternative pathway in order to avoid the consequences of the metabolic block present in the patient. Among other therapies, the authors discuss the use of zinc and tetrathiomolybdate to treat Wilson's disease and the use of cysteamine to treat nephropathic cystinosis.
Pathophysiology of Lysosomal Transport
The field of lysosomal transport has grown exponentially in the past decade. Research in this previously unknown function of lysosomes has resulted in understanding the metabolic defect in three inborn errors in metabolism: nephropathic cystinosis, cobalamin F-deficient methylmalonic aciduria, and Salla disease. Seventeen transport systems mediating the exodus from lysosomes of amino acids, sugars, nucleosides, phosphate, calcium, cobalamin, and sulfate have been described. Pathophysiology of Lysosomal Transport presents the current status in this field as described by the authors who made the original discoveries. Each chapter examines the pathological consequences resulting from a defect in a particular system. The book also examines the transfer of macromolecules into the lysosomes, describes the analogy between mammalian lysosomes and vacuoles of plants and fungi, and reviews non-mediated transport. A comprehensive chapter on the methodology required to perform lysosomal studies will benefit researchers undertaking investigations in this area.
Inside DNA and RNA
Cells are the basic units of life, but within them are even smaller structures that act as the machinery that keeps us alive. This include the key molecules in cellular biology, deoxyribonucleic acid and ribonucleic acid—better known as DNA and RNA. These teammates have essential jobs and they work together to make life possible. DNA stores and transfers genetic information, while RNA codes for amino acids and acts as a messenger in the making of proteins. This enlightening book erases much of the mystique surrounding the science of genetics, thanks to thorough explanations of DNA and RNA at work within the body. Numerous diagrams help make this potentially difficult topic more accessible.
Published Scientific Papers of the National Institutes of Health
Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.
Inside the World of Microbes
Microbes are everywhere! They live on and under the ground. They live in all kinds of water on Earth, even around the hottest deep-sea vents. They even live on and inside your body! Since the advent of powerful microscopes, scientists have been studying our world's smallest denizens. Many people get scared just hearing the words "bacteria," "fungus," and "virus" because of the diseases they cause. However, scientists have discovered many beneficial microbes that actually help support all life on Earth. Geneticists have sequenced the genomes of numerous microbes, extending our knowledge of the organisms and how they affect our lives.
Genomics
"Since the completion of the Human Genome Project, genetic studies has transitioned into an era of discovery. This book explores the breakthroughs in research that inform our understanding of ancestry, inheritance, epigenetics, health, and medicine." --
Scientific Directory and Annual Bibliography
Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.
Cecil Textbook of Medicine
The latest version of this superb resource delivers a fully integrated approach to the pathophysiology, diagnosis, and treatment of virtually every medical condition. Renowned authorities have meticulously revised this classic text to insure it reflects the current state of the field. The 21st Edition is concise, complete, highly readable, well illustrated-and a must for every successful practitioner. "The granddaddy of general internal medicine texts...Solidly written and effectively illustrated...and a comprehensive resource on diseases of adults." (JAMA, rev. of last ed.)
