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Identification of Biomarkers for Cancer Immunotherapy: From Bench to Bedside, volume I
During the past few decades, immunotherapy has become an established pillar of cancer treatment improving the survival of numerous patients with diverse solid and hematologic tumors. The leading causes behind the success are the discovery of immune checkpoint inhibitors (ICIs) and the development of chimeric antigen receptor (CAR) T/M/NK cells. As for ICIs, malignancies take advantage of the inhibitory programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) or cytotoxic T-lymphocyte-associated protein (CTLA-4) pathways to evade the immune system, and disruption of the axis by immune checkpoint inhibitors can achieve durable disease remissions, which has been prove...
Emerging Molecular Signaling Pathways and Therapeutic Targets in the Genitourinary Immune Microenvironment
It is well known that the immune microenvironment is critical to the progression of genitourinary malignancies and benign diseases. A variety of cellular and molecular properties of the immune microenvironment may influence disease outcome by altering the balance of suppressive versus inflammatory or cytotoxic responses. Emerging evidence suggests that immunoediting is a key factor of phenotypic change, immunological alterations caused by physical activity or drug treatments could promote antitumor or anti-inflammatory activity. Conversely, microenvironment deficits or dysregulation can instigate or worsen pathological progression, thereby contributing to urinary disease development and prog...
Green Connected Automated Transportation and Safety
These proceedings gather selected papers from the 11th International Conference on Green Intelligent Transportation Systems and Safety, held in Beijing, China on October 17-19, 2020. The book features cutting-edge studies on Green Intelligent Mobility Systems, the guiding motto being to achieve “green, intelligent, and safe transportation systems”. The contributions presented here can help promote the development of green mobility and intelligent transportation technologies to improve interconnectivity, resource sharing, flexibility and efficiency. Given its scope, the book will benefit researchers and engineers in the fields of Transportation Technology and Traffic Engineering, Automotive and Mechanical Engineering, Industrial and System Engineering, and Electrical Engineering alike. The readers will be able to find out the Advances in Green Intelligent Transportation System and Safety.
Wireless Sensor Networks
This book constitutes the refereed proceedings of the 11th China Conference on Wireless Sensor Networks, CWSN 2017, held in Tianjin, China, in October 2017. The 28 revised full papers were carefully reviewed and selected from 213 submissions. The papers are organized in topical sections on wireless sensor networks; energy efficiency and harvesting; data fusion; mobile computing and social services.
Proceedings of the 9th International Conference on Civil Engineering
This open access book is a compilation of selected papers from the 9th International Conference on Civil Engineering (ICCE2022). The work focuses on novel research findings on seismic technology of civil engineering structures, High-tech construction materials, digitalization of civil engineering, urban underground space development. The contents make valuable contributions to academic researchers and engineers.
Travel Guide of Hubei
This book is the volume of ''Travel Guide of Hubei'' among a series of travel books (''Travelling in China''). Its content is detailed and vivid.
Multifunctional Hydrogels
Hydrogels are important polymer-based materials with innate fascinating properties and applications: they are three-dimensional, hydrophilic, polymeric networks that can absorb large amounts of water or aqueous fluids and are biocompatible, mechanically flexible, and soft. The incorporation of functionalities to develop smart and bioactive platforms has led to a myriad of applications. This book offers a comprehensive overview of multifunctional hydrogels, covering fundamentals, properties, and advanced applications in a progressive way. While each chapter can be read stand-alone, together they clearly describe the fundamental concepts of design, synthesis, and fabrication, as well as proper...
Blockchain-based Internet of Things
This book presents an overview of the blockchain-based Internet of Things systems, along with the opportunities, challenges, and solutions in diverse fields such as business, education, agriculture, and healthcare. It discusses scalability, security, layers, threats, and countermeasures in blockchain-based Internet of Things network. Elaborates on the opportunities presented by combining blockchain with artificial intelligence on the Internet of Things systems in the management of food systems, and drug supply chains Explains the management of computationally intensive tasks in blockchain-based Internet of Things through the development of lightweight protocols Presents various applications in fields including logistics and the supply chain, automobile industry, smart housing, shared economy, and agriculture Provides insights into blockchain-based Internet of Things systems, along with their features, vulnerabilities, and architectural flaws The text is primarily written for graduate students, and academic researchers working in the fields of computer science and engineering, electrical engineering, and information technology
His Honey Lover
He was a descendant of the Chu Clan, and she was the neglected daughter of the Song Clan. She married him at such a young age. They had been married for two years, and she had struggled painfully in a marriage that was like a grave, but he had never once looked at her. She thought he had misunderstood her, until the woman returned. When she finally understood something, she realized that she could no longer extricate herself. ***
