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Transporters as Drug Targets
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.
New Psychoactive Substances
This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly developing phenomenon.
Neuropharmacology of New Psychoactive Substances (NPS)
Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon.
Neuroimmune System
The book explores the intricate connections between the nervous and immune systems in the context of neurodegenerative disorders, offering a comprehensive overview of the bidirectional communication between these systems and their implications for disease progression and therapeutic interventions. The book aims to understand the recent developments in the field of neuroimmune communication. Key Features: In-depth analysis of immunological biomarkers and therapeutic targets for neurodegenerative disorders. Exploration of the role of glial cells in neuroimmune interactions and their dual nature in disease pathology. Examination of short- and long-range interactions between the central nervous ...
Who's Who in Fluorescence 2007
The Journal of Fluorescence’s fifth Who’s Who directory publishes the names, contact details, specialty keywords, and a brief description of scientists employing fluorescence methodology and instrumentation in their working lives. In addition, it provides company contact details with a brief list of fluorescence-related products.
Who's Who in Fluorescence 2008
th The Who’s Who in Fluorescence 2008 is the 6 Volume of the Who’s Who Series. The previous five volumes (2003 - 2007) have been very well received indeed, with 1000’s of copies being distributed around the world, through conferences and workshops, as well as through internet book sites. Recently, the WWiF Volume was th disseminated at the 10 MAFS conference in Salzburg, Austria. The Volume was very well received indeed. We subsequently thank Professor Otto Wolfbeis for help in disseminating the Volume at the MAFS venue. This new 2008 Volume features some 418 entries from no fewer than 38 countries worldwide, as compared to 405 entries (35 different countries) in 2007 and 366 entries i...
Organic Cation Transporters in the Central Nervous System
Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com
Membrane Transport Mechanism
This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternati...
Who's Who in Fluorescence 2009
th The Who’s Who in Fluorescence 2009 is the 7 volume of the Who’s who series. The previous six volumes (2003 – 2008) have been very well received by the fluorescence community, with 1000’s of copies being distributed around the world, through conferences and workshops, as well as through internet book sites. In addition, the Institute of Fluorescence (http://theinstituteoffluorescence.com/) mailed 100’s of copies of the 2008 volume to contributors around the world. This new 2009 volume features some 419 entries from no fewer than 41 countries worldwide, as compared to 418 entries (38 different countries) in 2008 and 405 entries in the 2007 volume, respectively. We have received 29...
Who’s Who in Fluorescence 2004
The Who's Who in Fluorescence 2003 volume was published in November 2002. It featured some 312 personal entries from fluorescence workers all over the world. Initially we were unsure how useful the volume would be. However, it wasn't very long before we were inundated with requests for both bulk and personal orders. In addition a significant number of copies were freely distributed at conference venues, such as at the Biophysical Society meeting in San Antonio. Texas, March 2003, and at the Methods and Applications of Fluorescence Spectroscopy conference (MAFS) in Prague, Czech Republic, August 2003, where these two venues probably host the largest gathering of Fluorescence workers anywhere....
