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Clinical Cases in Primary Immunodeficiency Diseases
Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.
Cancer Immunology
This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.
New Trends in Software Methodologies, Tools and Techniques
Software is the essential enabler for the new economy and science. It creates new markets and new directions for a more reliable, flexible, and robust society. It empowers the exploration of our world in ever more depth. However, software often falls short behind our expectations. Current software methodologies, tools, and techniques remain expensive and not yet reliable for a highly changeable and evolutionary market. Many approaches have been proven only as case-by-case oriented methods. This book presents a number of new trends and theories in the direction in which we believe software science and engineering may develop to transform the role of software and science in tomorrow’s information society. This publication is an attempt to capture the essence of a new state of art in software science and its supporting technology. Is also aims at identifying the challenges such a technology has to master.
Intelligence Methods and Systems Advancements for Knowledge-Based Business
Knowledge is power: In todays era of knowledge-based economies, constantly changing business environments, severe competition, and globalization, gaining the knowledge edge will greatly empower an organization to stay on the cutting edge. Intelligence Methods and Systems Advancements for Knowledge-Based Business examines state-of-the-art research in decision sciences and business intelligence, and the applications of knowledge-based business with information systems. This comprehensive volume will provide researchers, academics, and business professionals with the research and inspiration they need to strengthen and empower their businesses in todays world.
Advances in Knowledge Discovery and Data Mining
This book constitutes the refereed proceedings of the 13th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2009, held in Bangkok, Thailand, in April 2009. The 39 revised full papers and 73 revised short papers presented together with 3 keynote talks were carefully reviewed and selected from 338 submissions. The papers present new ideas, original research results, and practical development experiences from all KDD-related areas including data mining, data warehousing, machine learning, databases, statistics, knowledge acquisition, automatic scientific discovery, data visualization, causal induction, and knowledge-based systems.
Web Information Systems Engineering – WISE 2007
This book constitutes the proceedings of the 8th International Conference on Web Information Systems Engineering, WISE 2007, held in Nancy, France, in December 2007. The papers are organized in topical sections on querying, trust, caching and distribution, interfaces, events and information filtering, data extraction, transformation, and matching, ontologies, rewriting, routing, and personalisation, agents and mining, QOS and management, modeling, and topics.
Intelligent Environments 2009
As computers are increasingly embedded into our everyday environments, the objects therein become augmented with sensors, processing and communication capabilities and novel interfaces. The capability for objects to perceive the environment, store and process data, pursue goals, reason about their intentions and coordinate actions in a holistic manner gives rise to the so-called Intelligent Environment (IE). In such environments, real space becomes augmented with digital content, thus transcending the limits of nature and of human perception. The result is a pervasive transparent infrastructure capable of recognizing, responding and adapting to individuals in a seamless and unobtrusive way. ...
