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Hamster Immune Responses in Infectious and Oncologic Diseases
This volume comprises the written contributions of participants in a symposium held in Dallas, Texas, June 3-5, 1980, entitled "HAMSTER IMMUNE RESPONSIVENESS AND EXPERIMENTAL MODELS OF INFECTIOUS AND ONCO LOGIC DISEASES". This meeting followed its predecessor, "Hamster Immune Responses: Experimental Models Linking Immunogenetics, Oncogene sis and Viral Immunity" by three years. This more recent meeting was more pointed in its focus and the contributions appeared to be more tightly associated. These meetings are part of an extend~d effort by experimentalists using the Syrian hamster as an animal model system to bring together workers in potentially related areas for the exchange of ideas and ...
Integrated Cancer Management
This definitive, up-to-the-minute reference explores the range of metabolic, nutritional, immunologic, and psychological changes that can occur while treating local, regional, and distant cancer, and examines the influence of these factors on outcomes and recovery. Includes clearly written, concise summaries of oncological therapy emphasizing c
Dermal and Ocular Toxicology
Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.
The Skin and Gene Therapy
This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.
DERMATOTOXICOLOGY 4ED
A guide to the field of dermatotoxicology. This edition includes fundamental information on the mechanisms of action of toxic substances on skin as well as practical information on the varied responses of skin to specific toxic substances and approaches to evaluating dermal toxicity. Other topics discussed include: hostile natural elements, such as ultraviolet radiation, poisonous plants, man-made detergents and chemicals; problems associated with chronic occupational skin exposure to toxic chemicals; animal alternative research programmes; carcinogenic and Photo Carcinogenic Potential Of Xenobiotic Chemicals; Oculotoxicity; Risk assessment and management; and cosmetic safety. Anatomical factors affecting barrier functions/ lipids of the permeability barrier/the skin immune system.
Cancer Vaccines
With ten million persons afflicted each year, no one is entirely immune to cancer and its devastating effects on individuals and families. But recent advances in the development of cancer vaccines—either as therapeutic agents or as preventative measures—are hopeful indicators of progress in this field. This volume comprises invited chapters from world-renowned researchers and clinicians that shed light on recent steps forward in immunotherapeutic and preventive approaches for future cancer vaccines. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Vaccine Design
Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996
Immunology of Breast Cancer
In this issue, exciting new directions are outlined by fourteen groups of investigators working on critical areas in Breast Cancer Immunology. In the clinic, patients are responding to Her-2 peptides or GM-CSF transfected tumor cell vaccines. Futhermore, tumors under vaccine induced immune attack can prime the host to additional antigens. Selected chemotherapeutic agents are used to further vaccine efficacy. These promising results highlight the value of breast cancer immunotherapy. Although the clinical progress is exciting, significant challenges remain. Many tumor-associated antigens are self-antigens and vigorous measures will be required to induce consistent and sustained anti-tumor imm...
Melanoma
Strategies of treatment involving therapeutic proteins, irnrnune immune cells, or cel lular protein targets are those of greatest potential for further reducing mortality from melanoma. Therapeutic proteins or cells may inhibit melanoma cell growth either by augmentation of immune cell function or by inhibition of angiogenesis. Cytokines and melanoma antigens may be used either in vivo as a vaccine to stimulate irnrnune immune cell cell function or ex vivo to stimulate or proliferate cells for infusion. Alternatively, alteration in melanoma cell growth can occur through inhibition of protein signal transduction pathways within melanoma cells or in the endothelial cells constituting the neces...
