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Proteolysis in Cell Functions
The proteolytic enzymes have an essential function in all cells. Their activities are regulated by the rate of synthesis, activation of proenzymes and by the rate of synthesis of their inhibitors. They are synthesized in ribosomes like any other proteins and transported to various storage organelles or secreted from the cells and are activated in the pericellular space or in interstitium. Various cells and tissues have their characteristic enzyme patterns which serve their specific functions. Proteolytic enzymes take part and often have a regulatory role in numerous phases of cell function, e.g. cell division, migration, apoptotic as well as necrotic cell death etc. Diseases in which proteolysis has been subject of active research are e.g. cancer metastasis, viral infections, e.g. HIV, and Alzheimer's disease. They are also an essential part in any tissue remodelling, wound healing, throughout the kingdom of fauna and flora.
Cellular Peptidases in Immune Functions and Diseases
Proceedings of an international conference held in Magdeburg, Germany, November 3-5, 1996
Handbook of Proteolytic Enzymes
Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing f...
Unconventional collagens
This Protein Profile issue covers collagens VI, VII, VIII, IX, X, XII, XIV, XVI, and XIX. It contains information about constituents chains, biosynthesis and post-translational modifications, genes, molecular and supramolecular assemblies, interactions, tissue distribution, and degradation, genetic and acquired diseases. Also available are the EBI sequence data and alignments and a full bibliography.
Handbook of Proteolytic Enzymes, Volume 1
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
Past, Present And Future Of Psychiatry - Ix World Congress Of Psychiatry (In 2 Volumes)
This volume presents the highlights of the IX World Congress of Psychiatry. The congress was a major event with the participation of over 6000 scientists from all over the world with the scientific program covering all aspects of contemporary psychiatry. The 200 papers selected for this volume provide an insight into recent advances in psychiatry. They discuss a wide spectrum of subjects ranging from the diagnosis and treatment of mental illnesses to critical issues affecting the future of mental health care throughout the world. Authors include leading psychiatric clinicians and researchers throughout the world as well as international mental health policy makers.
Intracellular Protein Catabolism II
This book contains most of the papers presented . at the Second International Symposium on Intracellular Protein OItaboiism, which was held on May 26-30,1975 in Ljubljana, Yugoslavia. The papers presented in this book cover a wide variety of areas related to protein turnover and responsible enzymes. The symposium attracted about one hundred parti cipants, and the cordial atmosphere, the frank discussions and the exchange of ideas were a stimulant for all those attending_ During the last decade, investigations in the wide field of intracellular protein catabolism have been rapidly taken up in many laboratories, because the mechanisms and regulation of degradative processes are rather less stu...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
