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Geometric Optimal Control
This book gives a comprehensive treatment of the fundamental necessary and sufficient conditions for optimality for finite-dimensional, deterministic, optimal control problems. The emphasis is on the geometric aspects of the theory and on illustrating how these methods can be used to solve optimal control problems. It provides tools and techniques that go well beyond standard procedures and can be used to obtain a full understanding of the global structure of solutions for the underlying problem. The text includes a large number and variety of fully worked out examples that range from the classical problem of minimum surfaces of revolution to cancer treatment for novel therapy approaches. Al...
Optimal Control for Mathematical Models of Cancer Therapies
This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.
Mathematical Methods and Models in Biomedicine
Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phe...
Systems Modelling and Optimization Proceedings of the 18th IFIP TC7 Conference
Top researchers in optimization and control from around the world gathered in Detroit for the 18th annual IFIP TC7 Conference on Systems Modelling and Optimization held in July 1997. The papers presented in this volume were carefully selected from among the 250 plenary, invited, and contributed works presented at the conference. The editors chose these papers to represent the myriad and diverse range of topics within the field and to disseminate important new results. It includes recent results on a broad variety of modelling and control applications, particularly automotive modelling and control, along with recent theoretical advances.
Optimal Control
February 27 - March 1, 1997, the conference Optimal Control: The ory, Algorithms, and Applications took place at the University of Florida, hosted by the Center for Applied Optimization. The conference brought together researchers from universities, industry, and government laborato ries in the United States, Germany, Italy, France, Canada, and Sweden. There were forty-five invited talks, including seven talks by students. The conference was sponsored by the National Science Foundation and endorsed by the SIAM Activity Group on Control and Systems Theory, the Mathe matical Programming Society, the International Federation for Information Processing (IFIP), and the International Association f...
Nonlinear Controllability and Optimal Control
This outstanding reference presents current, state-of-the-art research on importantproblems of finite-dimensional nonlinear optimal control and controllability theory. Itpresents an overview of a broad variety of new techniques useful in solving classicalcontrol theory problems.Written and edited by renowned mathematicians at the forefront of research in thisevolving field, Nonlinear Controllability and Optimal Control providesdetailed coverage of the construction of solutions of differential inclusions by means ofdirectionally continuous sections ... Lie algebraic conditions for local controllability... the use of the Campbell-Hausdorff series to derive properties of optimal trajectories... the Fuller phenomenon ... the theory of orbits ... and more.Containing more than 1,300 display equations, this exemplary, instructive reference is aninvaluable source for mathematical researchers and applied mathematicians, electrical andelectronics, aerospace, mechanical, control, systems, and computer engineers, and graduatestudents in these disciplines .
Chaotic Dynamics of Fractional Discrete Time Systems
The book reviews the application of discrete fractional operators in diverse fields such as biological and chemical reactions, as well as chaotic systems, demonstrating their applications in physics. The dynamical analysis is carried out using equilibrium points of the system for studying their stability properties and the chaotic behaviors are illustrated with the help of bifurcation diagrams and Lyapunov exponents. The book is divided into three parts. Part I deals with the application of discrete fractional operators in chemical reaction-based systems with biological significance. Two different chemical reaction models are analysed- one being disproportionation of glucose, which plays an ...
New Challenges for Cancer Systems Biomedicine
The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.
Differential Geometry and Control
Contains papers from a summer 1997 meeting on recent developments and important open problems in geometric control theory. Topics include linear control systems in Lie groups and controllability, real analytic geometry and local observability, singular extremals of order 3 and chattering, infinite time horizon stochastic control problems in hyperbolic three space, and Monge-Ampere equations. No index. Annotation copyrighted by Book News, Inc., Portland, OR.
