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User-Friendly Tools Applied to Genetics or Systems Biology
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Computational Systems Biology
This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Theoretical and Applied Aspects of Systems Biology
This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology.
Nucleic Acids Hybridization
Several approaches, such as microarray hybridization, have become extremely popular tools for specialists in biochemistry and biomedicine, while the potential of many other advantageous techniques seems to be underestimated. Written by an international team of authors, this book details the current state-of-art in hybridization techniques. Coverage includes experimental protocols along with comprehensive and detailed method descriptions.
Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Recent advances in the understanding of microbiota in health and diseases are presented in this special issue of Frontiers in Immunology and Frontiers in Microbiology as well as their impact on the immune system that can lead to the development of pathologies. Potential perspectives and biomarkers are also addressed. We offer this Research Topic involving 64 articles and 501 authors to discuss recent advances regarding: 1. An overview of the human microbiota and its capacity to interact with the human immune system and metabolic processes, 2. New developments in understanding the immune system’s strategies to respond to infections and escape strategies used by pathogens to counteract such responses, 3. The link between the microbiota and pathology in terms of autoimmunity, allergy, cancers and other diseases.
Laws: Rigidity And Dynamics
Laws: are they a human invention or are they independent and indifferent to our existence? Are they there to be discovered, dictated, and enforced? Are they absolute and rigid, or do they evolve? Are they applicable in some cases and irrelevant in others? A group of multidisciplinary fellows and world-leading mentors from all habitable continents met at the Nanyang Technological University, Singapore and the IAS University of Birmingham, UK, to share and challenge their opinions on the subject. The results of their deliberations are to be found in the chapters of this book. The existence, dynamics, and flexibility of laws are analyzed in the arts, economy, engineering, history, philosophy, a...
The Science and Applications of Synthetic and Systems Biology
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging in...
Systems Biology
First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.
