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Chirality from Dynamic Kinetic Resolution
The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resol...
Organocatalytic Dynamic Kinetic Resolution
In a classical kinetic resolution, two enantiomers of a racemate are transformed into chiral products at different rates with a maximum theoretical yield of 50%. However, the need to reduce costs and waste in synthesis have led to efforts to develop novel resolution procedures proceeding beyond this 50% limited yield. This has led to the evolution of classical kinetic resolution into dynamic kinetic resolution (DKR), allowing a quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It is only in the last two decades that chiral green organocatalysts have been demonstrated to be capable of promoting DKRs considerably expanding the synthetic scope of the powerful concept of DKR. Collecting all the developments in the field of DKR, this book shows that a wide variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations. It is a great resource for academics and industrialists interested in green enantioselective catalytic reactions.
Enantioselective Titanium-catalysed Transformations
Chiral titanium complexes are low-cost, low-toxicity and high-efficiency catalysts. Impressive progress on enantioselective titanium-catalysed transformations has been achieved in the past seven years, with exciting new discoveries ranging from basic reactions to novel methodologies. Despite this, the field has not been substantially reviewed since 2008.This book contains up to date research and covers all types of enantioselective transformations using chiral titanium catalysts. It illustrates the economic, health, and environmental benefits of chiral titanium catalysts, showing the types of highly enantioselective reactions that they are able to induce are unlimited.Work presented here is aimed at researchers in organic and catalytic chemistry, and has been carefully curated to encourage future research possibilities.
Enantioselective Nickel-catalysed Transformations
Presenting the impressive range of uses that have been found for nickel chiral catalysts, for researchers and industrialists in organic chemistry, synthesis and medicinal chemistry.
Chiral Sulfur Ligands
The goal of this book is to show the high potential of chiral sulfur-containing ligands to promote numerous asymmetric catalytic transformations. These ligands can now be recognised as real competitors to the more usual phosphorus- or nitrogen-containing ligands.
Asymmetric Domino Reactions
This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006.
Asymmetric Metal Catalysis in Enantioselective Domino Reactions
Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino react...
Enantioselective Nickel-catalysed Transformations
Due to the lower costs of nickel catalysts and the high abundance of nickel complexes, enantioselective nickel-mediated transformations have received a continuous and growing attention in recent years. This book demonstrates the diversity of chemistry catalysed by chiral nickel catalysts. Discussing several different enantioselective transformations, this book presents the impressive range of uses that have been found for novel and already known nickel chiral catalysts, from basic organic transformations to completely novel methodologies including fascinating one-pot domino and multicomponent reactions. This much-needed book is ideal for researchers and industrialists in organic chemistry, synthesis and medicinal chemistry.
Recent Developments in Asymmetric Organocatalysis
The aim of this book is to cover the very recent developments in asymmetric organocatalysis, focussing on those published since the beginning of 2008. The last decade has witnessed an explosive growth in the field of asymmetric organocatalysis with an impressive amount of new catalysts, novel methodologies, and applications in numerous reaction types, such as nucleophilic substitutions, addition reactions, as well as cycloadditions, oxidations, reductions, kinetic resolutions, and miscellaneous reactions. This very diverse and intensely developing field is too wide to cover in a single review. The timeliness of the book together with the expected impact is excellent, since nowadays asymmetri...
Enantioselective Multicatalysed Tandem Reactions
Chiral molecules are needed for the production of many pharmaceuticals and materials, and catalytic asymmetric synthesis provides a method for the preparation of such chiral products. For the synthesis of complex molecules, such as natural products and biologically active compounds, more than one catalytic reaction may be necessary and tandem catalysis refers to the combination of catalytic reactions into one synthesis. By combing catalysts it enables a more efficient, economical and selective one pot approach for complex molecule synthesis which could not be achieved through single specific catalytic systems. The challenge is finding the right catalyst which is compatible with other catalys...
