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Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias
Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory experiments create new opportunities to unravel the mechanisms of arrhythmogenesis. This thesis describes the roles of integrative computational modeling in unraveling the arrhythmogenic consequences of calcium-handling abnormalities.
Information Security
NASA relies extensively on information systems and networks to pioneer space exploration, scientific discovery, and aeronautics research. Many of these systems and networks are interconnected through the Internet, and may be targeted by evolving and growing cyber threats from a variety of sources. This report: (1) determines whether NASA has implemented appropriate controls to protect the confidentiality, integrity, and availability of the information and systems used to support NASA¿s mission directorates; and (2) assesses NASA¿s vulnerabilities in the context of prior incidents and corrective actions. The report examined network and system controls in place at 3 centers; and analyzed IS policies, plans, and reports.
H.R. 3268
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